PDF(Pubmed)
Abstract：
Fuchs endothelial corneal dystrophy (FECD) is a complex genetic disorder characterized by the slow and progressive degeneration of corneal endothelial cells. Thus, it may result in corneal endothelial decompensation and irreversible corneal edema. Moreover, FECD is associated with alterations in all corneal layers, such as thickening of the Descemet membrane, stromal scarring, subepithelial fibrosis, and the formation of epithelial bullae. Hence, anterior segment imaging devices that enable precise measurement of functional and anatomical changes in the cornea are essential for the management of FECD. In this review, the authors will introduce studies on the application of various imaging modalities, such as anterior segment optical coherence tomography, Scheimpflug corneal tomography, specular microscopy, in vitro confocal microscopy, and retroillumination photography, in the diagnosis and monitoring of FECD and discuss the results of these studies. The application of novel technologies, including image processing technology and artificial intelligence, that are expected to further enhance the accuracy, precision, and speed of the imaging technologies will also be discussed.
摘要：
Fuchs内皮角膜营养不良（FECD）是一种复杂的遗传性疾病，其特征是角膜内皮细胞的缓慢和进行性变性。因此，它可能导致角膜内皮代偿失调和不可逆的角膜水肿。此外，FECD与所有角膜层的改变有关，如Descemet膜的增厚，基质瘢痕,上皮下纤维化，和上皮性大疱的形成。因此，能够精确测量角膜功能和解剖学变化的眼前段成像设备对于FECD的管理至关重要。在这次审查中,作者将介绍各种成像方式的应用研究，如眼前段光学相干断层扫描，Scheimpflug角膜断层扫描，镜面显微镜，体外共聚焦显微镜，和逆向摄影，在FECD的诊断和监测中，并讨论这些研究的结果。新技术的应用，包括图像处理技术和人工智能，预计将进一步提高准确性，精度,和速度的成像技术也将讨论。
