背景:炎症是我们身体抵抗感染的免疫反应,病原体,病毒,和外部刺激。炎症可分为两种类型:急性炎症和慢性炎症。非甾体抗炎药(NSAID)用于治疗急性和慢性炎性疾病。然而,这些治疗有各种副作用,如降低愈合效率,消化性溃疡,胃肠道毒性,等。方法:这篇综述评估了来自各种天然来源的抗炎肽(AIP)的潜力,比如藻类,真菌,植物,动物,和海洋生物。专注于富含半胱氨酸和蛋氨酸的肽,含硫氨基酸以其在抑制炎症中的作用而闻名。
结果:由于它们不同的生物活性,穿透细胞的能力,和低细胞毒性,生物活性肽作为可能的治疗剂引起了人们的兴趣。AIP的利用在与炎症相关的疾病的治疗中显示出巨大的潜力。AIP可以从各种天然来源获得,如藻类,真菌,植物,和动物。半胱氨酸和蛋氨酸是含硫氨基酸,有助于消除自由基,因此有助于治疗炎性疾病。
结论:这篇综述专门研究了AIP的几种来源,包括含有大量半胱氨酸和甲硫氨酸的肽。此外,还讨论了这些氨基酸的生物学特性和肽递送的进展。
BACKGROUND: Inflammation serves as our body\'s immune response to combat infections, pathogens, viruses, and external stimuli. Inflammation can be classified into two types: acute inflammation and chronic inflammation. Non-steroidal anti-inflammatory medications (NSAIDs) are used to treat both acute and chronic inflammatory disorders. However, these treatments have various side effects such as reduced healing efficiency, peptic ulcers, gastrointestinal toxicities, etc. METHOD: This
review assesses the potential of anti-inflammatory peptides (AIPs) derived from various natural sources, such as algae, fungi, plants, animals, and marine organisms. Focusing on peptides rich in cysteines and methionine, sulphur-containing amino acids known for their role in suppression of inflammation.
RESULTS: Due to their varied biological activity, ability to penetrate cells, and low cytotoxicity, bioactive peptides have garnered interest as possible therapeutic agents. The utilisation of AIPs has shown great potential in the treatment of disorders associated with inflammation. AIPs can be obtained from diverse natural sources such as algae, fungi, plants, and animals. Cysteine and methionine are sulphur-containing amino acids that aid in the elimination of free radicals, hence assisting in the treatment of inflammatory diseases.
CONCLUSIONS: This
review specifically examines several sources of AIPs including peptides that contain numerous cysteines and methionine. In addition, the biological characteristics of these amino acids and advancements in peptide delivery are also discussed.