Abstract：
Multiple myeloma (MM) is an incurable malignancy of clonal plasma cells. Various diagnostic methods are used in parallel to accurately determine stage and severity of the disease. Identifying a biomarker or a panel of biomarkers could enhance the quality of medical care that patients receive by adopting a more personalized approach. Metabolomics utilizes high-throughput analytical platforms to examine the levels and quantities of biochemical compounds in biosamples. The aim of this review was to conduct a systematic literature search for potential metabolic biomarkers that may aid in the diagnosis and prognosis of MM. The review was conducted in accordance with PRISMA recommendations and was registered in PROSPERO. The systematic search was performed in PubMed, CINAHL, SciFinder, Scopus, The Cochrane Library and Google Scholar. Studies were limited to those involving people with clinically diagnosed MM and healthy controls as comparators. Articles had to be published in English and had no restrictions on publication date or sample type. The quality of articles was assessed according to QUADOMICS criteria. A total of 709 articles were collected during the literature search. Of these, 436 were excluded based on their abstract, with 26 more removed after a thorough review of the full text. Finally, 16 articles were deemed relevant and were subjected to further analysis of their data. A number of promising candidate biomarkers was discovered. Follow-up studies with large sample sizes are needed to determine their suitability for clinical applications.
摘要：
多发性骨髓瘤是克隆性浆细胞的无法治愈的恶性肿瘤。并行使用各种诊断方法来准确地确定疾病的阶段和严重程度。识别生物标志物或一组生物标志物可以通过采用更个性化的方法来提高患者接受的医疗质量。代谢组学利用高通量分析平台来检查生物样品中生化化合物的水平和数量。这篇综述的目的是进行系统的文献搜索，寻找可能有助于MM诊断和预后的潜在代谢生物标志物。审查是根据PRISMA建议进行的，并在PROSPERO注册。PubMed中的系统搜索，CINAHL,SciFinder,Scopus,执行了Cochrane图书馆和GoogleScholar。研究仅限于以临床诊断为MM的人和健康对照者作为比较者。文章必须以英文出版，并且对出版日期或样本类型没有限制。根据QUADOMICS标准评估文章的质量。文献检索共收集709篇。其中,436根据其摘要被排除在外，在彻底审查全文后，又删除了26个。最后,16篇文章被认为是相关的，并对其数据进行了进一步分析。发现了许多有希望的候选生物标志物。需要大样本量的后续研究来确定其适用性或临床应用。
