■本研究旨在总结哌拉西林引起的药物不良反应(ADR)的病例报告,并探讨其在现实环境中对人体器官的影响。
■哌拉西林不良反应的病例报告是通过检索PubMed、Embase,WebofScience,CNKI,万方,和VIP从成立到2022年12月。
■最终纳入了170例患者。结果显示,哌拉西林引起的不良反应主要与全身有关,其次是血液系统,皮肤和软组织,还有神经系统.最常报告的病例包括过敏性休克,药物热,皮疹,和血小板减少症.最严重的不良反应为过敏性休克和大疱性表皮坏死松解症。此外,比较哌拉西林单药和两种哌拉西林/β-内酰胺酶抑制剂复合制剂引起的全身不良反应。说明书中未提及的ADR包括抽搐或幻觉和Kounis综合征(KS)。
■本综述表明,与哌拉西林相关的最严重的不良反应是中毒性表皮坏死松解症和过敏性休克。哌拉西林引起的罕见不良反应,比如肌阵挛性抽搐,幻觉,KS,已确定。哌拉西林/舒巴坦和哌拉西林钠国产制剂最常见的症状是呼吸困难。
UNASSIGNED: This study aimed to summarize
case reports of adverse drug reactions (ADRs) caused by piperacillin and explore their effects on human organs in real-world settings.
UNASSIGNED: Case reports of piperacillin ADRs were collected by searching databases such as PubMed, Embase, Web of Science, CNKI, WanFang, and VIP from inception to December 2022.
UNASSIGNED: A total of 170 patients were ultimately included. The results revealed that ADRs caused by piperacillin were primarily associated with the entire body, followed by the blood system, skin and soft tissues, and the nervous system. The most frequently reported cases included anaphylactic shock, drug fever, rash, and thrombocytopenia. The most severe ADRs were identified as anaphylactic shock and bullous epidermal necrolysis. Furthermore, a comparison was made between systemic adverse reactions caused by piperacillin as a single drug and two composite preparations of piperacillin/β-lactamase inhibitor. ADRs not mentioned in the instructions included convulsions or hallucinations and Kounis syndrome (KS).
UNASSIGNED: This review suggests that the most severe ADRs associated with piperacillin are toxic epidermal necrolysis and anaphylactic shock. Rare ADRs caused by piperacillin, such as myoclonic jerks, hallucinations, and KS, were identified. The most common symptom with domestic preparations of piperacillin/sulbactam and piperacillin sodium was dyspnea.