关键词: ACUTE PANCREATITIS ADVERSE DRUG REACTIONS PANCREAS

Mesh : Humans Transgender Persons / statistics & numerical data Retrospective Studies Male Female Middle Aged Pancreatitis / epidemiology chemically induced Adult Incidence Hormone Replacement Therapy / adverse effects statistics & numerical data methods Aged

来  源:   DOI:10.1136/bmjgast-2023-001312   PDF(Pubmed)

Abstract:
BACKGROUND: There is limited data on the incidence of gastrointestinal-specific pathology in gender non-conforming (GNC) populations.
METHODS: Retrospective analysis of pancreatitis incidence rates in transgender and GNC persons exposed and not exposed to gender-affirming hormone therapy (GAHT).
RESULTS: 7 of the 1333 patients on hormone therapy had an incidence of pancreatitis. 0 of the 615 patients with no history of GAHT use developed pancreatitis. Representing a 6.96 (95% CI 2.76 to 848.78) for the development of pancreatitis in patients with exposure to GAHT therapy.
CONCLUSIONS: Clinicians working with GNC individuals should be aware of this possible association.
摘要:
背景:关于性别不合格(GNC)人群中胃肠道特异性病理发生率的数据有限。
方法:回顾性分析暴露和未暴露于性别确认激素治疗(GAHT)的变性人和GNC人群胰腺炎发生率。
结果:1333例接受激素治疗的患者中有7例发生胰腺炎。无GAHT使用史的615例患者中,有0例发展为胰腺炎。在接受GAHT治疗的患者中,胰腺炎的发展为6.96(95%CI2.76至848.78)。
结论:与GNC个体一起工作的临床医生应该意识到这种可能的关联。
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