目的：腺病毒-36（Ad-36）血清阳性已被证明与肥胖的病因有关。这项研究的目的是检查患有多囊卵巢综合征（PCOS）的肥胖和正常体重患者的Ad-36阳性。
方法：分为两组，包括92名和110名受试者。本研究为前瞻性病例对照研究。酶免疫测定方法用于定量测定血清样品中人Ad-36特异性抗体(Abs)。年龄,体重指数（BMI），记录参与者的空腹血糖水平和胰岛素水平.将PCOS和对照组患者分为两组：超重组BMI≥25kg/m2，非肥胖组BMI<25kg/m2。
结果：发现PCOS组的Ad-36Ab阳性明显高于对照组（p<0.001）。Ad-36Ab阳性在PCOS肥胖组中显著高于对照组肥胖组(p<0.001)。在逻辑回归分析中，Ad-36Ab阳性和BMI≥25kg/m2被确定为PCOS的独立预测因子。
结论：Ad-36Ab阳性在肥胖/超重PCOS患者中显著增高。通过治疗Ad-36可以预防PCOS患者的肥胖。
OBJECTIVE: Adenovirus-36 (Ad-36) seropositivity has been shown to be involved in the aetiology of obesity. The aim of this study was to examine Ad-36 positivity in obese and normal-weight patients with polycystic ovary syndrome (PCOS).
METHODS: There were two groups including 92 and 110 subjects. This study was a prospective
case-control study. The enzyme-immunoassay method was used to quantitatively determine antibodies (Abs) specific to human Ad-36 in the serum samples. Age, body mass index (BMI), fasting glucose levels and insulin levels of the participants were recorded. The PCOS and control group patients were divided into two groups: the overweight group with BMI ≥25 kg/m2 and non-obese group with BMI <25 kg/m2.
RESULTS: Ad-36 Ab positivity in the PCOS group was found to be significantly higher than that in the control group (p < 0.001). Ad-36 Ab positivity was significantly higher in the PCOS obese group than in the control obese group (p < 0.001). Ad-36 Ab positivity and BMI ≥25 kg/m2 were identified as independent predictors of PCOS in logistic regression analysis.
CONCLUSIONS: Ad-36 Ab positivity was significantly higher in the obese/overweight PCOS patients. Obesity can be prevented in patients with PCOS by treating Ad-36.
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