%0 Journal Article
%T Adenovirus-36 infection and obesity: A case control study of Turkish women with polycystic ovary syndrome.
%A Cakmakliogullari EK
%A Eroglu S
%J Diabetes Metab Syndr
%V 15
%N 1
%D Jan-Feb 2021
%M 33581595
暂无%R 10.1016/j.dsx.2021.01.019
%X <B>OBJECTIVE: </B>Adenovirus-36 (Ad-36) seropositivity has been shown to be involved in the aetiology of obesity. The aim of this study was to examine Ad-36 positivity in obese and normal-weight patients with polycystic ovary syndrome (PCOS).<BR><B>METHODS: </B>There were two groups including 92 and 110 subjects. This study was a prospective case-control study. The enzyme-immunoassay method was used to quantitatively determine antibodies (Abs) specific to human Ad-36 in the serum samples. Age, body mass index (BMI), fasting glucose levels and insulin levels of the participants were recorded. The PCOS and control group patients were divided into two groups: the overweight group with BMI ≥25 kg/m2 and non-obese group with BMI <25 kg/m2.<BR><B>RESULTS: </B>Ad-36 Ab positivity in the PCOS group was found to be significantly higher than that in the control group (p < 0.001). Ad-36 Ab positivity was significantly higher in the PCOS obese group than in the control obese group (p < 0.001). Ad-36 Ab positivity and BMI ≥25 kg/m2 were identified as independent predictors of PCOS in logistic regression analysis.<BR><B>CONCLUSIONS: </B>Ad-36 Ab positivity was significantly higher in the obese/overweight PCOS patients. Obesity can be prevented in patients with PCOS by treating Ad-36.