METHODS: There were two groups including 92 and 110 subjects. This study was a prospective case-control study. The enzyme-immunoassay method was used to quantitatively determine antibodies (Abs) specific to human Ad-36 in the serum samples. Age, body mass index (BMI), fasting glucose levels and insulin levels of the participants were recorded. The PCOS and control group patients were divided into two groups: the overweight group with BMI ≥25 kg/m2 and non-obese group with BMI <25 kg/m2.
RESULTS: Ad-36 Ab positivity in the PCOS group was found to be significantly higher than that in the control group (p < 0.001). Ad-36 Ab positivity was significantly higher in the PCOS obese group than in the control obese group (p < 0.001). Ad-36 Ab positivity and BMI ≥25 kg/m2 were identified as independent predictors of PCOS in logistic regression analysis.
CONCLUSIONS: Ad-36 Ab positivity was significantly higher in the obese/overweight PCOS patients. Obesity can be prevented in patients with PCOS by treating Ad-36.
方法:分为两组,包括92名和110名受试者。本研究为前瞻性病例对照研究。酶免疫测定方法用于定量测定血清样品中人Ad-36特异性抗体(Abs)。年龄,体重指数(BMI),记录参与者的空腹血糖水平和胰岛素水平.将PCOS和对照组患者分为两组:超重组BMI≥25kg/m2,非肥胖组BMI<25kg/m2。
结果:发现PCOS组的Ad-36Ab阳性明显高于对照组(p<0.001)。Ad-36Ab阳性在PCOS肥胖组中显著高于对照组肥胖组(p<0.001)。在逻辑回归分析中,Ad-36Ab阳性和BMI≥25kg/m2被确定为PCOS的独立预测因子。
结论:Ad-36Ab阳性在肥胖/超重PCOS患者中显著增高。通过治疗Ad-36可以预防PCOS患者的肥胖。