背景:为了研究使用三维(3D)超声和虚拟现实系统进行早孕期胎儿器官体积测量的可重复性。
方法:在一项基于人群的前瞻性队列研究中,3名超声检查者收集了25例妊娠早期胎儿的3D超声数据集。我们使用V-scope应用程序对胎儿心脏进行虚拟现实体积评估,肺,还有肾脏.所有测量均由两名独立研究人员进行。
结果:对胎儿心脏体积测量的观察者内部分析,肺,肾脏显示组内相关系数≥0.86,平均差≤8.3%,变异系数≤22.8%。观察者间分析显示,右肺容量测量结果足够一致,但是左肺观察者之间的测量差异一致,心,和肾脏体积测量值(p值<0.05)。
结论:我们观察到足够的观察者内可重复性,但是孕早期胎儿心脏的总体观察者间可重复性不佳,肺,和肾脏体积测量使用创新的虚拟现实方法。在现阶段,这些测量可能有希望在研究环境中使用。测量的再现性可以通过新颖的后处理算法进一步改进。
BACKGROUND: To investigate the reproducibility of first-trimester fetal organ volume measurements using three-dimensional (3D) ultrasound and a Virtual Reality system.
METHODS: Within a population-based prospective cohort
study, 3D ultrasound datasets of 25 first-trimester fetuses were collected by three sonographers. We used the V-scope application to perform Virtual Reality volume assessments of the fetal heart, lungs, and kidneys. All measurements were performed by two independent researchers.
RESULTS: Intraobserver analyses for volume measurements of the fetal heart, lungs, and kidneys showed intraclass correlation coefficients ≥0.86, mean differences ≤8.3%, and coefficients of variation ≤22.8%. Interobserver analyses showed sufficient agreement for right lung volume measurements, but consistent measurement differences between observers for left lung, heart, and kidney volume measurements (p-values <0.05).
CONCLUSIONS: We observed sufficient intraobserver reproducibility, but overall suboptimal interobserver reproducibility for first-trimester fetal heart, lung, and kidney volume measurements using an innovative Virtual Reality approach. In the current stage, these measurements might be promising for the use in research settings. The reproducibility of the measurements might be further improved by novel post-processing algorithms.