蒙特利尔认知评估(MoCA)测试对检测轻度认知障碍或早期痴呆具有很高的敏感性和特异性。MoCA评分如何与正电子发射断层扫描成像的发现相关,然而,尚不清楚。
这项前瞻性研究检查了日本版本的MoCA(MoCA-J)测试与轻度认知障碍受试者的脑淀粉样蛋白沉积或脑葡萄糖代谢之间的关系。
共有125名轻度认知障碍的受试者接受了MoCA-J测试,淀粉样蛋白和18F-氟代脱氧葡萄糖正电子发射断层扫描。采用线性相关分析和多元线性回归分析探讨MoCA-J评分与人口学特征的关系,淀粉样蛋白沉积,和大脑葡萄糖代谢。此外,统计参数映射8用于MoCA-J评分和脑葡萄糖代谢的体素回归分析。
MoCA-J评分与年龄显著相关,多年的教育,和迷你精神状态考试成绩。在调整了年龄之后,性别,和教育,MoCA-J评分与淀粉样蛋白滞留呈负相关(β=-0.174,p=0.031),与脑葡萄糖代谢呈正相关(β=0.183,p=0.044)。统计参数图显示日文版MoCA评分与双侧额叶和顶叶葡萄糖代谢相关,和左边的precuneus。
MoCA-J总评分与轻度认知障碍受试者的淀粉样蛋白沉积和额叶和顶叶葡萄糖代谢相关。我们的研究结果支持MoCA-J测试用于筛查阿尔茨海默病高风险受试者的有用性。
The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear.
This prospective study examined the relationship between the Japanese version of the MoCA (MoCA-J) test and brain amyloid deposition or cerebral glucose metabolism among subjects with mild cognitive impairment.
A total of 125 subjects with mild cognitive impairment underwent the MoCA-J test, and amyloid- and 18F-fluorodeoxyglucose- positron emission tomography. Linear correlation analysis and multiple linear regression analysis were conducted to investigate the relationship between the MoCA-J score and demographic characteristics, amyloid deposition, and cerebral glucose metabolism. Moreover, Statistical Parametric Mapping 8 was used for a voxel-wise regression analysis of the MoCA-J score and cerebral glucose metabolism.
The MoCA-J score significantly correlated with age, years of education, and the Mini-Mental State Examination score. After adjusting for age, sex, and education, the MoCA-J score significantly correlated negatively with amyloid retention (β= -0.174, p= 0.031) and positively with cerebral glucose metabolism (β= 0.183, p= 0.044). Statistical Parametric Mapping showed that Japanese version of MoCA score correlated with glucose metabolism in the bilateral frontal and parietal lobes, and the left precuneus.
The total MoCA-J score correlated with amyloid deposition and frontal and parietal glucose metabolism in subjects with mild cognitive impairment. Our findings support the usefulness of the MoCA-J test for screening subjects at high risk for Alzheimer\'s disease.