PDF(Pubmed)
Abstract：
We herein report a case of anti-gamma aminobutyric acid type A receptor antibody-associated encephalitis (anti-GABAA-RE) with progressive aphasia and generalized tonic-clonic seizures. Cerebral magnetic resonance imaging (MRI) showed cortical brain lesions coupled with hypermetabolism on fluorodeoxyglucose-positron emission tomography. After two courses of methylprednisolone pulse therapy, improvements in neurological symptoms without sequelae and the total disappearance of MRI lesions were observed. Upon encountering patients with refractory status epilepticus, multifocal cerebral MRI lesions, and suspected autoimmune encephalitis, especially in cases with thymoma, it would be prudent to suspect anti-GABAA-RE and consider the evaluation of anti-GABAA receptor antibody and methylprednisolone pulse therapy.
摘要：
我们在此报告一例抗γ氨基丁酸A型受体抗体相关脑炎（抗GABAA-RE）伴有进行性失语和全身性强直阵挛性癫痫发作。脑磁共振成像（MRI）在氟脱氧葡萄糖-正电子发射断层扫描上显示皮质脑病变与代谢亢进。经过两个疗程的甲基强的松龙脉冲治疗，观察到神经系统症状改善，无后遗症，MRI病变完全消失。在遇到患有难治性癫痫持续状态的患者时，多灶性脑MRI病变，怀疑是自身免疫性脑炎，尤其是胸腺瘤患者,谨慎的做法是怀疑抗GABAA-RE,并考虑评估抗GABAA受体抗体和甲基强的松龙冲击治疗.
