Abstract：
This study aimed to assess the role of preoperative 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for predicting late neck metastasis in clinically node-negative (cN0) early-stage oral squamous cell carcinoma (OSCC). We retrospectively investigated the standardized uptake value (SUV) parameters in patients with late neck metastasis based on the neck node level. The study population consisted of 16 patients with cT1N0 or cT2N0 oral SCC who were evaluated with dual-phase FDG-PET/CT and were treated with local resection of the primary tumor and watchful waiting for neck management. The SUV at each level was measured on the early and delayed images, and the laterality of the SUV was calculated. The laterality on the delayed images significantly differed between positive and negative pairs at the levels Ib (p = 0.002) and IIb (p = 0.013); a cut-off value of 1.4 yielded a true-positive rate of 50% and a false-positive rate of 6%. The laterality of FDG-uptake should be used to stratify the risk for nodal-level metastasis.
摘要：
本研究旨在评估术前18F-脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）/计算机断层扫描（CT）在临床淋巴结阴性（cN0）早期口腔鳞状细胞癌（OSCC）中预测晚期颈部转移的作用。我们根据颈淋巴结水平回顾性调查了晚期颈转移患者的标准化摄取值（SUV）参数。研究人群包括16例cT1N0或cT2N0口腔SCC患者，他们接受了双相FDG-PET/CT评估，并接受了原发性肿瘤的局部切除和观察等待颈部治疗。每个级别的SUV都是在早期和延迟图像上测量的，并计算了SUV的侧向性。在Ib（p=0.002）和IIb（p=0.013）水平上，阳性和阴性对之间的延迟图像的侧向性显着不同；临界值为1.4，真阳性率为50％，假阳性率为6％。FDG摄取的侧向性应用于对淋巴结转移的风险进行分层。
