目的:TRPS1是一个新的,乳腺癌敏感标志物(BC)。唾液腺和乳房都是外分泌腺;因此,它们的肿瘤可能具有相似的形态和免疫表型。在唾液腺型BC中,据报道,TRPS1在分泌性癌(SC)中呈阳性,但在腺泡细胞癌(AcCC)和大多数腺样囊性癌(AdCC)中呈阴性。唾液导管癌(SDC)的一个子集对TRPS1呈阳性。在这里,我们研究了TRPS1免疫组织化学在唾液腺肿瘤(SGT)中的表达。
方法:回顾性检索得到110SGT(原发97例,转移13例)。TRPS1免疫组织化学评分为阴性,低正,中间积极,或强烈的积极。
结果:TRPS1在78%(14/18)的多形性腺瘤(PA)病例中表达,但在所有Warthin肿瘤中均为阴性/低阳性(6/6[100%])。在基底细胞腺瘤(BCA)中,TRPS1在基质细胞中的表达是中等到强(13/14[92%]),而导管或基底细胞显示低表达。TRPS1在恶性SGT中的表达不同,在100%(15/15)的AdCC中有中等至强染色,100%(5/5)的基底细胞腺癌,100%(3/3)的导管内癌,89%(8/9)的多形性腺癌,89%(7/8)的SDCs;在100%(3/3)的SCs中观察到阴性/低阳性表达,89%(8/9)的AcCC,和50%(3/3)的粘液表皮样癌。此外,在转移到肺的SGT中观察到强和中等的TRPS1表达,淋巴结,和软组织。
结论:总体而言,TRPS1在PA以及恶性和转移性SGT中强烈表达。此外,TRPS1在BCA基质细胞中呈阳性,但在导管和基底细胞中呈阴性或低阳性。
TRPS1 is a new, sensitive marker for breast carcinoma (BC). Salivary glands and breasts are both exocrine glands; thus, their tumors may share similar morphology and immunophenotype. Among salivary gland-type BC, TRPS1 is reported to be positive in secretory carcinomas (SCs) but negative in acinic cell carcinomas (AciCCs) and most adenoid cystic carcinomas (AdCCs). A subset of salivary duct carcinomas (SDCs) is positive for TRPS1. Herein, we investigate TRPS1 immunohistochemical expression in salivary gland tumors (SGTs).
A retrospective search yielded 110 SGTs (97 primary and 13 metastatic). TRPS1 immunohistochemistry was scored as negative, low positive, intermediate positive, or strongly positive.
TRPS1 was expressed in 78% (14/18) of pleomorphic adenoma (PA) cases but negative/low positive in all Warthin tumors (6/6 [100%]). In basal cell adenoma (BCA), TRPS1 expression was intermediate to strong (13/14 [92%]) in the stromal cells, whereas ductal or basal cells showed low expression. TRPS1 expression varied in malignant SGTs, with intermediate to strong staining in 100% (15/15) of AdCCs, 100% (5/5) of basal cell adenocarcinoma, 100% (3/3) of intraductal carcinoma, 89% (8/9) of polymorphous adenocarcinoma, and 89% (7/8) of SDCs; negative/low positive expression was observed in 100% (3/3) of SCs, 89% (8/9) of AciCCs, and 50% (3/3) of mucoepidermoid carcinomas. In addition, strong and intermediate TRPS1 expression was observed in metastatic SGT to the lungs, lymph nodes, and soft tissue.
Overall, TRPS1 is strongly expressed in PA as well as malignant and metastatic SGT. In addition, TRPS1 is positive in stromal cells of BCA but negative or low positive in ductal and basal cells.