Abstract：
Aberrant β-catenin distribution has been theorized as a predictive biomarker for recurrence in early stage, low grade endometrioid endometrial cancer.
This retrospective single-institution cohort study reviewed 410 patients with endometrial cancer from May 2018 to May 2022. Only endometrioid histology was included. Demographic and clinicopathological data were collected from the medical records. Univariate and multivariate logistic regressions, and sensitivity analyses for early stage, low grade and no specific molecular profile (NSMP) tumors were performed.
297 patients were included for analysis. Most patients were over 60 years old, White, and with a BMI >30 and early stage low grade disease. Aberrant β-catenin distribution was found in 135 patients (45.5%) and wild type membranous β-catenin distribution in 162 (54.5%). While TP53 mutation correlated with endometrial cancer recurrence in this cohort (OR = 4.78), aberrant β-catenin distribution did not correlate in the overall population (OR = 0.75), the early stage low grade cancers (OR = 0.84), or the NSMP group (OR = 1.41) on univariate or multivariate analysis. No correlation between β-catenin distribution and local (OR = 0.61) or distant recurrences (OR = 0.90) was detected.
Aberrant β-catenin distribution did not significantly correlate with recurrence in endometrioid endometrial cancer, nor in the early stage, low grade and NSMP sub-cohorts.
This retrospective single-institution cohort study reviewed 410 patients with endometrial cancer from May 2018 to May 2022. Only endometrioid histology was included. Demographic and clinicopathological data were collected from the medical records. Univariate and multivariate logistic regressions, and sensitivity analyses for early stage, low grade and no specific molecular profile (NSMP) tumors were performed.
297 patients were included for analysis. Most patients were over 60 years old, White, and with a BMI >30 and early stage low grade disease. Aberrant β-catenin distribution was found in 135 patients (45.5%) and wild type membranous β-catenin distribution in 162 (54.5%). While TP53 mutation correlated with endometrial cancer recurrence in this cohort (OR = 4.78), aberrant β-catenin distribution did not correlate in the overall population (OR = 0.75), the early stage low grade cancers (OR = 0.84), or the NSMP group (OR = 1.41) on univariate or multivariate analysis. No correlation between β-catenin distribution and local (OR = 0.61) or distant recurrences (OR = 0.90) was detected.
Aberrant β-catenin distribution did not significantly correlate with recurrence in endometrioid endometrial cancer, nor in the early stage, low grade and NSMP sub-cohorts.
摘要：
目的：β-连环蛋白分布异常已被理论化为早期复发的预测生物标志物，低级别子宫内膜样子宫内膜癌。
方法：这项回顾性单机构队列研究回顾了2018年5月至2022年5月的410例子宫内膜癌患者。仅包括子宫内膜样组织学。从医疗记录中收集人口统计学和临床病理数据。单变量和多变量逻辑回归，以及早期阶段的敏感性分析，进行了低级别和无特异性分子谱(NSMP)肿瘤.
结果：297例患者被纳入分析。大多数病人超过60岁，白色,BMI>30和早期低度疾病。在135例患者中发现β-catenin分布异常（45.5％），在162例患者中发现野生型膜β-catenin分布异常（54.5％）。虽然TP53突变与子宫内膜癌复发相关（OR=4.78），异常β-连环蛋白分布在总体人群中不相关(OR=0.75)，早期低级别癌症（OR=0.84），或NSMP组(OR=1.41)进行单因素或多因素分析。未检测到β-连环蛋白分布与局部（OR=0.61）或远处复发（OR=0.90）之间的相关性。
结论：β-catenin分布异常与子宫内膜样子宫内膜癌的复发无显著相关性，也不是在早期阶段，低年级和NSMP子队列。
方法：这项回顾性单机构队列研究回顾了2018年5月至2022年5月的410例子宫内膜癌患者。仅包括子宫内膜样组织学。从医疗记录中收集人口统计学和临床病理数据。单变量和多变量逻辑回归，以及早期阶段的敏感性分析，进行了低级别和无特异性分子谱(NSMP)肿瘤.
结果：297例患者被纳入分析。大多数病人超过60岁，白色,BMI>30和早期低度疾病。在135例患者中发现β-catenin分布异常（45.5％），在162例患者中发现野生型膜β-catenin分布异常（54.5％）。虽然TP53突变与子宫内膜癌复发相关（OR=4.78），异常β-连环蛋白分布在总体人群中不相关(OR=0.75)，早期低级别癌症（OR=0.84），或NSMP组(OR=1.41)进行单因素或多因素分析。未检测到β-连环蛋白分布与局部（OR=0.61）或远处复发（OR=0.90）之间的相关性。
结论：β-catenin分布异常与子宫内膜样子宫内膜癌的复发无显著相关性，也不是在早期阶段，低年级和NSMP子队列。
