背景:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者缺氧程度和睡眠时间对前庭功能的影响。进一步研究OSAHS低氧水平和低氧持续时间对前庭功能的影响,并进一步研讨了OSAHS最长呼吸暂停时光与前庭诱发肌电位(VEMP)异常率与前庭功效神经性麻痹(CP)的关系。
方法:本研究共纳入87例OSAHS患者和47例健康人。性别没有差异,匹配实验组的年龄和体重指数(BMI)值。排除其他系统的其他疾病。所有参与者都填写了嗜睡问卷(即,Epworth嗜睡量表和STOP-BANG问卷)和头晕障碍量表(DHI)。此外,热量测试,位置测试,耳蜗电图,和VEMP测试用于评估所有参与者的前庭功能。还进行了多导睡眠图(PSG)。
结果:目前的调查产生了以下三个主要发现:(I)体重指数与管麻痹之间存在显着相关性[CP;P=0.014,比值比(OR)=1.791,95%置信区间(CI):1.125-2.851],DHI评分与VEMP结果之间存在显着正相关关系(P=0.0061,OR=3.667<0.05)OHS
结论:OSAHS患者前庭功能异常率高于健康人。OSAHS间歇性缺氧可影响内耳前庭功能,长期缺氧的持续时间越长,前庭功能损伤越严重。
BACKGROUND: To investigate the effects of hypoxia degree and sleep duration on vestibular function in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. We made further study of the low oxygen levels of OSAHS and hypoxic duration on the impact of vestibular function, and further studied the OSAHS the longest apnea time and Vestibular Evoked Myogenic Potential (VEMP) abnormal rate and the relationship between the vestibular function of canal paralysis (CP).
METHODS: A total of 87 OSAHS patients and 47 healthy individuals were enrolled in this study. There was no difference in gender, age and body mass index (BMI) values in matched experimental groups. Other diseases of other systems were excluded. All the participants completed sleepiness questionnaires (i.e., the Epworth sleepiness scale and the STOP-BANG questionnaire) and the Dizziness Handicap Inventory (DHI). Additionally, a caloric test, positional test, electrocochleogram, and VEMP test were administered to evaluate the vestibular function of all the participants. A polysomnography (PSG) was also performed.
RESULTS: The current investigation generated the following three major findings: (I) there was a significant correlation between body mass index and canal paresis [CP; P=0.014, odds ratio (OR) =1.791, 95% confidence interval (CI): 1.125-2.851] and a significant positive correlation between the DHI score and VEMP results (P=0.0061, OR =3.667, 95% CI: 1.449-9.276); (II) the CP abnormality rate of the OSAHS group was significantly higher than that of the control group (P<0.05); (III) there was a significant correlation between the longest apnea duration and the DHI score (r=-0.191, P<0.05).
CONCLUSIONS: The abnormality rate of the vestibular function of OSAHS patients is higher than that of healthy people. OSAHS intermittent hypoxia can affect vestibular function in the inner ear, and the longer the duration of prolonged hypoxia, the more serious the vestibular function damage.