Abstract：
OBJECTIVE: The main purpose of this study was to investigate the usefulness of wide band tympanometry (WBT) as a diagnostic tool for Ménière\'s disease (MD) by comparing differences in absorbance measures between normal hearing ears and patient diagnosed with MD.
METHODS: We conducted a retrospective case-control study. From a cohort of 116 patients diagnosed with Ménière disease, 52 MD patients and 99 normal hearing adults with no history of otological disease served as subjects. Wideband tympanometry was conducted using at Titan Impedance module and audiometry was performed with a MADSEN Astera2. Mean energy absorbance curves with 95% confidence intervals were computed across cases with MD and controls in the frequency range 226-8000 Hz. An overall test for difference between curves of cases and controls was calculated by multivariate analysis of variance.
RESULTS: The MD group and the subpopulations of MD patients who fulfilled the International criteria for MD showed a statistically significant lower absorbance at tympanic peak pressure compared to the control group (p < 0.001). No overlap of confidence intervals between mean curves was found within the frequency range of 2000-4000 Hz.
CONCLUSIONS: Absorbance measures obtained by WBT were able to distinguish between MD ears and normal ears within the frequency range of 2000-4000 Hz. The results indicate that WBT potentially could be a useful and simple non-invasive diagnostic tool for MD. However, more research on the association between absorbance measures and inner ear pathologies is needed.
METHODS: We conducted a retrospective case-control study. From a cohort of 116 patients diagnosed with Ménière disease, 52 MD patients and 99 normal hearing adults with no history of otological disease served as subjects. Wideband tympanometry was conducted using at Titan Impedance module and audiometry was performed with a MADSEN Astera2. Mean energy absorbance curves with 95% confidence intervals were computed across cases with MD and controls in the frequency range 226-8000 Hz. An overall test for difference between curves of cases and controls was calculated by multivariate analysis of variance.
RESULTS: The MD group and the subpopulations of MD patients who fulfilled the International criteria for MD showed a statistically significant lower absorbance at tympanic peak pressure compared to the control group (p < 0.001). No overlap of confidence intervals between mean curves was found within the frequency range of 2000-4000 Hz.
CONCLUSIONS: Absorbance measures obtained by WBT were able to distinguish between MD ears and normal ears within the frequency range of 2000-4000 Hz. The results indicate that WBT potentially could be a useful and simple non-invasive diagnostic tool for MD. However, more research on the association between absorbance measures and inner ear pathologies is needed.
摘要：
目的：本研究的主要目的是通过比较正常听耳和被诊断为MD的患者之间的吸光度测量差异，研究宽带鼓室测量（WBT）作为Ménière病（MD）诊断工具的有用性。
方法：我们进行了回顾性病例对照研究。从116名被诊断患有梅尼埃病的患者中，52例MD患者和99例无耳科疾病史的正常听力成人作为研究对象。使用Titan阻抗模块进行宽带鼓室测定，并使用MADSENAstera2进行听力测定。在频率范围226-8000Hz的MD和对照病例中计算具有95%置信区间的平均能量吸收曲线。通过多变量方差分析计算病例和对照曲线之间差异的总体检验。
结果：与对照组相比，MD组和符合国际MD标准的MD患者亚群在鼓室峰压下的吸光度具有统计学意义（p<0.001）。在2000-4000Hz的频率范围内，平均曲线之间的置信区间没有重叠。
结论：通过WBT获得的吸光度测量能够在2000-4000Hz的频率范围内区分MD耳朵和正常耳朵。结果表明，WBT可能是一种有用且简单的MD非侵入性诊断工具。然而,我们需要更多研究吸光度测量与内耳病变之间的关联.
方法：我们进行了回顾性病例对照研究。从116名被诊断患有梅尼埃病的患者中，52例MD患者和99例无耳科疾病史的正常听力成人作为研究对象。使用Titan阻抗模块进行宽带鼓室测定，并使用MADSENAstera2进行听力测定。在频率范围226-8000Hz的MD和对照病例中计算具有95%置信区间的平均能量吸收曲线。通过多变量方差分析计算病例和对照曲线之间差异的总体检验。
结果：与对照组相比，MD组和符合国际MD标准的MD患者亚群在鼓室峰压下的吸光度具有统计学意义（p<0.001）。在2000-4000Hz的频率范围内，平均曲线之间的置信区间没有重叠。
结论：通过WBT获得的吸光度测量能够在2000-4000Hz的频率范围内区分MD耳朵和正常耳朵。结果表明，WBT可能是一种有用且简单的MD非侵入性诊断工具。然而,我们需要更多研究吸光度测量与内耳病变之间的关联.
