■梅尼埃病,以间歇性眩晕发作为特征,波动性的感觉神经性听力损失,耳鸣,和听觉压力,是人类眩晕的常见原因。梅尼埃病的发病机制尚不清楚。当前的研究旨在描述在接受迷宫切除术的梅尼埃病患者的内耳中发现的一种新的病理变化。
■这项回顾性病例对照研究是对21例接受迷宫切除术的MD患者进行的。对15例诊断为听神经瘤或颈静脉球瘤的患者进行了同期检查,作为对照。描述了患者的临床信息和膜的病理特征。
■新的病理组织是密封圆窗的病态膜结构,以淋巴管形成为特征。组织化学和免疫荧光染色为D2-40,LYVE-1,podoplanin,和PROX1,它们是淋巴管的经典标记。透射电镜显示,淋巴毛细血管缺乏典型的基底膜,末端呈盲状,由单层内皮细胞组成,相邻毛细血管上皮细胞之间具有瓣膜连接结构。
■这是人类内耳淋巴管的首次报道,这个病理结构是一个全新的发现。淋巴管可能由于内耳的炎症或压力代偿失调而发展,这表明内耳在某些炎症和液体流量依赖的病理条件下可以反应性地形成淋巴管。目前的发现有助于提高我们对梅尼埃病发病机理的认识。
UNASSIGNED: Meniere disease, characterized by intermittent episodes of vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural pressure, is a common cause of vertigo in humans. The pathogenesis of Meniere disease remains unknown. The current study aimed to describe a novel pathological change discovered in the inner ears of patients with Meniere disease who underwent labyrinthectomy.
UNASSIGNED: This retrospective case-control study was conducted with 21 patients with MD who underwent labyrinthectomy. A total of 15 patients diagnosed with acoustic neuroma or glomus jugular tumor were review over the same period of time as control. The clinical information of the patients and the pathological features of the membrane are described.
UNASSIGNED: The new pathological tissue was a morbid membrane structure sealing the round window, characterized by the formation of lymphatic capillaries. Histochemical and immunofluorescent staining was positive for D2-40, LYVE-1, podoplanin, and PROX1, which are the classical markers of the lymphatic vessels. Transmission electron microscopy revealed that the lymph capillaries lacked a typical basement membrane and that their ends were blind, composed of a single layer of endothelial cells with valval connection structures between adjacent capillary epithelial cells.
UNASSIGNED: This is the first report of lymphatic vessels in the human inner ear, and this pathological structure is a completely new discovery. The lymphatic vessels may develop due to inflammation or decompensation of pressure in the inner ear, suggesting that the inner ear can reactively form lymphatic vessels in some inflammation and fluid flow-dependent pathological conditions. The current findings help in improving our understanding of the pathogenesis of Meniere disease.