Abstract：
Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2\'-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.
摘要：
人乳寡糖(HMO)已被认为是婴儿发育的黄金标准。3-岩藻糖基乳糖(3-FL),作为公认的安全卫生组织之一，代表HMO领域内的核心三糖；然而，与广泛研究的2'-岩藻糖基乳糖相比，它受到的关注相对较少。这篇综述的目的是全面总结3-FL对健康的影响，包括它对肠道微生物群增殖的影响，抗菌作用，免疫调节，抗病毒保护，和大脑成熟。此外,讨论还涵盖了3-FL的商业应用和监管批准状态。最后,有组织地介绍3-FL的大规模生产方法，旨在提供全面的指南，突出当前的优化策略和挑战。
