%0 Journal Article
%T Recent advances of 3-fucosyllactose in health effects and production.
%A Du Z
%A Li Z
%A Guang C
%A Zhu Y
%A Mu W
%J Arch Microbiol
%V 206
%N 9
%D 2024 Aug 14
%M 39143417
%F 2.667
%R 10.1007/s00203-024-04104-2
%X Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2'-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.