{Reference Type}: Journal Article
{Title}: Recent advances of 3-fucosyllactose in health effects and production.
{Author}: Du Z;Li Z;Guang C;Zhu Y;Mu W;
{Journal}: Arch Microbiol
{Volume}: 206
{Issue}: 9
{Year}: 2024 Aug 14
{Factor}: 2.667
{DOI}: 10.1007/s00203-024-04104-2
{Abstract}: Human milk oligosaccharides (HMOs) have been recognized as gold standard for infant development. 3-Fucosyllactose (3-FL), being one of the Generally Recognized as Safe HMOs, represents a core trisaccharide within the realm of HMOs; however, it has received comparatively less attention in contrast to extensively studied 2'-fucosyllactose. The objective of this review is to comprehensively summarize the health effects of 3-FL, including its impact on gut microbiota proliferation, antimicrobial effects, immune regulation, antiviral protection, and brain maturation. Additionally, the discussion also covers the commercial application and regulatory approval status of 3-FL. Lastly, an organized presentation of large-scale production methods for 3-FL aims to provide a comprehensive guide that highlights current strategies and challenges in optimization.