HLTF 解决 G4s 并促进 G4 诱导的复制叉减慢以维持基因组稳定性。
关键词: DNA replication stress response DNA translocase G-quadruplex HLTF MSH2 PrimPol RNA-DNA hybrid alternative lengthening of telomeres genome stability nucleic acid secondary structure
Mesh : Humans Genomic Instability DNA Replication G-Quadruplexes Transcription Factors / metabolism genetics DNA-Binding Proteins / metabolism genetics MutS Homolog 2 Protein / metabolism genetics DNA Primase / metabolism genetics Telomere Homeostasis DNA Damage HEK293 Cells Multifunctional Enzymes / metabolism genetics DNA-Directed DNA Polymerase
来 源:
DOI:10.1016/j.molcel.2024.07.018
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