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Abstract：
BACKGROUND: The volumes of the hippocampal subfields are related to poststroke cognitive dysfunctions. However, it remains unclear whether contralesional hippocampal subfield volume contributes to cognitive impairment. This study aimed to investigate the volumetric differences in the contralesional hippocampal subfields between patients with left and right hemisphere strokes (LHS/RHS). Additionally, correlations between contralesional hippocampal subfield volumes and clinical outcomes were explored.
METHODS: Fourteen LHS (13 males, 52.57 ± 7.10 years), 13 RHS (11 males, 51.23 ± 15.23 years), and 18 healthy controls (11 males, 46.94 ± 12.74 years) were enrolled. Contralesional global and regional hippocampal volumes were obtained with T1-weighted images. Correlations between contralesional hippocampal subfield volumes and clinical outcomes, including the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE), were analyzed. Bonferroni correction was applied for multiple comparisons.
RESULTS: Significant reductions were found in contralesional hippocampal as a whole (adjusted p = .011) and its subfield volumes, including the hippocampal tail (adjusted p = .005), cornu ammonis 1 (CA1) (adjusted p = .002), molecular layer (ML) (adjusted p = .004), granule cell and ML of the dentate gyrus (GC-ML-DG) (adjusted p = .015), CA3 (adjusted p = .009), and CA4 (adjusted p = .014) in the RHS group compared to the LHS group. MoCA and MMSE had positive correlations with volumes of contralesional hippocampal tail (p = .015, r = .771; p = .017, r = .763) and fimbria (p = .020, r = .750; p = .019, r = .753) in the LHS group, and CA3 (p = .007, r = .857; p = .009, r = .838) in the RHS group, respectively.
CONCLUSIONS: Unilateral stroke caused volumetric differences in different hippocampal subfields contralesionally, which correlated to cognitive impairment. RHS leads to greater volumetric reduction in the whole contralesional hippocampus and specific subfields (hippocampal tail, CA1, ML, GC-ML-DG, CA3, and CA4) compared to LHS. These changes are correlated with cognitive impairments, potentially due to disrupted neural pathways and interhemispheric communication.
METHODS: Fourteen LHS (13 males, 52.57 ± 7.10 years), 13 RHS (11 males, 51.23 ± 15.23 years), and 18 healthy controls (11 males, 46.94 ± 12.74 years) were enrolled. Contralesional global and regional hippocampal volumes were obtained with T1-weighted images. Correlations between contralesional hippocampal subfield volumes and clinical outcomes, including the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE), were analyzed. Bonferroni correction was applied for multiple comparisons.
RESULTS: Significant reductions were found in contralesional hippocampal as a whole (adjusted p = .011) and its subfield volumes, including the hippocampal tail (adjusted p = .005), cornu ammonis 1 (CA1) (adjusted p = .002), molecular layer (ML) (adjusted p = .004), granule cell and ML of the dentate gyrus (GC-ML-DG) (adjusted p = .015), CA3 (adjusted p = .009), and CA4 (adjusted p = .014) in the RHS group compared to the LHS group. MoCA and MMSE had positive correlations with volumes of contralesional hippocampal tail (p = .015, r = .771; p = .017, r = .763) and fimbria (p = .020, r = .750; p = .019, r = .753) in the LHS group, and CA3 (p = .007, r = .857; p = .009, r = .838) in the RHS group, respectively.
CONCLUSIONS: Unilateral stroke caused volumetric differences in different hippocampal subfields contralesionally, which correlated to cognitive impairment. RHS leads to greater volumetric reduction in the whole contralesional hippocampus and specific subfields (hippocampal tail, CA1, ML, GC-ML-DG, CA3, and CA4) compared to LHS. These changes are correlated with cognitive impairments, potentially due to disrupted neural pathways and interhemispheric communication.
摘要：
背景：海马亚区的体积与卒中后认知功能障碍有关。然而,目前尚不清楚海马亚区容积是否会导致认知障碍.这项研究旨在调查左右半球中风（LHS/RHS）患者之间对比海马亚区的体积差异。此外,研究了对比区海马亚场体积与临床结局之间的相关性。
方法：14名LHS（13名男性，52.57±7.10年），13RHS（11名男性，51.23±15.23年），和18名健康对照(11名男性，纳入46.94±12.74岁）。用T1加权图像获得对比的整体和区域海马体积。对比区海马子场体积与临床结果之间的相关性，包括蒙特利尔认知评估（MoCA）和迷你精神状态检查（MMSE），进行了分析。Bonferroni校正应用于多重比较。
结果：在整个对比区海马（调整后的p=.011）及其子场体积中发现了显着减少，包括海马尾部（调整后的p=0.005），玉米氨1(CA1)(调整后p=.002)，分子层（ML）（调整后的p=.004），颗粒细胞和齿状回的ML（GC-ML-DG）（调整后的p=.015），CA3（调整后的p=.009），与LHS组相比，RHS组的CA4（调整后的p=0.014）。在LHS组中，MoCA和MMSE与对比海马尾部（p=.015，r=.771；p=.017，r=.763）和菌毛（p=.020，r=.750；p=.019，r=.753）的体积呈正相关，和CA3（p=.007，r=.857；p=.009，r=.838）在RHS组中，分别。
结论：单侧卒中引起不同海马子场的体积差异。这与认知障碍有关。RHS导致整个对比海马和特定子场的体积减少（海马尾部，CA1,ML,GC-ML-DG,CA3和CA4）与LHS相比。这些变化与认知障碍有关，可能是由于神经通路和半球间通讯中断。
方法：14名LHS（13名男性，52.57±7.10年），13RHS（11名男性，51.23±15.23年），和18名健康对照(11名男性，纳入46.94±12.74岁）。用T1加权图像获得对比的整体和区域海马体积。对比区海马子场体积与临床结果之间的相关性，包括蒙特利尔认知评估（MoCA）和迷你精神状态检查（MMSE），进行了分析。Bonferroni校正应用于多重比较。
结果：在整个对比区海马（调整后的p=.011）及其子场体积中发现了显着减少，包括海马尾部（调整后的p=0.005），玉米氨1(CA1)(调整后p=.002)，分子层（ML）（调整后的p=.004），颗粒细胞和齿状回的ML（GC-ML-DG）（调整后的p=.015），CA3（调整后的p=.009），与LHS组相比，RHS组的CA4（调整后的p=0.014）。在LHS组中，MoCA和MMSE与对比海马尾部（p=.015，r=.771；p=.017，r=.763）和菌毛（p=.020，r=.750；p=.019，r=.753）的体积呈正相关，和CA3（p=.007，r=.857；p=.009，r=.838）在RHS组中，分别。
结论：单侧卒中引起不同海马子场的体积差异。这与认知障碍有关。RHS导致整个对比海马和特定子场的体积减少（海马尾部，CA1,ML,GC-ML-DG,CA3和CA4）与LHS相比。这些变化与认知障碍有关，可能是由于神经通路和半球间通讯中断。
