Abstract：
In vivo antigenotoxic activity of BP-C2 composition (at doses of 60, 80, and 120 mg/kg) based on polyphenolic compounds derived from hydrolyzed lignin was evaluated in mouse germ cells. The BP-C2 composition dose-dependently reduced the aneugenic activity of topoisomerase II inhibitor etoposide in mouse oocytes without affecting the clastogenic activity of the genotoxicant. In mouse testicular cells, the BP-C2 composition reduced the DNA-damaging activity of the pro-oxidant genotoxicant dioxidine, but not etoposide. The cytoprotective activity of BP-C2 composition was revealed in relation to etoposide-induced cytotoxicity.
摘要：
在小鼠生殖细胞中评估了基于衍生自水解木质素的多酚化合物的BP-C2组合物（剂量为60、80和120mg/kg）的体内抗遗传毒性活性。BP-C2组合物剂量依赖性地降低拓扑异构酶II抑制剂依托泊苷在小鼠卵母细胞中的非活性活性,而不影响基因毒物的致裂活性。在小鼠睾丸细胞中，BP-C2组合物降低了促氧化剂基因毒性二氧西汀的DNA损伤活性，但不是依托泊苷。揭示了BP-C2组合物的细胞保护活性与依托泊苷诱导的细胞毒性有关。
