%0 Journal Article
%T Antigenotoxic Activity of Polyphenolic Composition BP-C2 in Mouse Germ Cells In Vivo.
%A Zhanataev AK
%A Anisina EA
%A Malikova AD
%A Pligina KL
%A Pigarev SE
%A Fedoros EI
%A Durnev AD
%A Anisimov VN
%J Bull Exp Biol Med
%V 177
%N 3
%D 2024 Jul 11
%M 39127976
%F 0.737
%R 10.1007/s10517-024-06182-0
%X In vivo antigenotoxic activity of BP-C2 composition (at doses of 60, 80, and 120 mg/kg) based on polyphenolic compounds derived from hydrolyzed lignin was evaluated in mouse germ cells. The BP-C2 composition dose-dependently reduced the aneugenic activity of topoisomerase II inhibitor etoposide in mouse oocytes without affecting the clastogenic activity of the genotoxicant. In mouse testicular cells, the BP-C2 composition reduced the DNA-damaging activity of the pro-oxidant genotoxicant dioxidine, but not etoposide. The cytoprotective activity of BP-C2 composition was revealed in relation to etoposide-induced cytotoxicity.