{Reference Type}: Journal Article
{Title}: Antigenotoxic Activity of Polyphenolic Composition BP-C2 in Mouse Germ Cells In Vivo.
{Author}: Zhanataev AK;Anisina EA;Malikova AD;Pligina KL;Pigarev SE;Fedoros EI;Durnev AD;Anisimov VN;
{Journal}: Bull Exp Biol Med
{Volume}: 177
{Issue}: 3
{Year}: 2024 Jul 11
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06182-0
{Abstract}: In vivo antigenotoxic activity of BP-C2 composition (at doses of 60, 80, and 120 mg/kg) based on polyphenolic compounds derived from hydrolyzed lignin was evaluated in mouse germ cells. The BP-C2 composition dose-dependently reduced the aneugenic activity of topoisomerase II inhibitor etoposide in mouse oocytes without affecting the clastogenic activity of the genotoxicant. In mouse testicular cells, the BP-C2 composition reduced the DNA-damaging activity of the pro-oxidant genotoxicant dioxidine, but not etoposide. The cytoprotective activity of BP-C2 composition was revealed in relation to etoposide-induced cytotoxicity.