PDF(Pubmed)
Abstract：
To investigate epidemiology of and risk factors for laboratory-confirmed mpox during the 2022 outbreak in Nigeria, we enrolled 265 persons with suspected mpox. A total of 163 (61.5%) were confirmed to have mpox; 137 (84.0%) were adults, 112 (68.7%) male, 143 (87.7%) urban/semi-urban dwellers, 12 (7.4%) self-reported gay men, and 3 (1.8%) female sex workers. Significant risk factors for adults were sexual and nonsexual contact with persons who had mpox, as well as risky sexual behavior. For children, risk factors were close contact with an mpox-positive person and prior animal exposure. Odds of being mpox positive were higher for adults with HIV and lower for those co-infected with varicella zoster virus (VZV). No children were HIV-seropositive; odds of being mpox positive were higher for children with VZV infection. Our findings indicate mpox affects primarily adults in Nigeria, partially driven by sexual activity; childhood cases were driven by close contact, animal exposure, and VZV co-infection.
摘要：
为了调查2022年尼日利亚爆发期间实验室确认的水痘的流行病学和危险因素，我们纳入了265名疑似水痘患者.共有163人(61.5%)被证实患有水痘；137人(84.0%)为成年人，112（68.7%）男性，143名(87.7%)城市/半城市居民，12名（7.4%）自我报告的男同性恋者，和3名(1.8%)女性性工作者。成年人的重要危险因素是与患痘的人发生性接触和非性接触，以及危险的性行为。对于孩子们来说,危险因素是与水痘阳性者的密切接触和先前的动物暴露.患有HIV的成年人的水痘阳性几率较高，而患有水痘带状疱疹病毒（VZV）的人则较低。没有儿童是HIV-血清阳性;与VZV感染的儿童是水痘阳性的几率较高。我们的发现表明，在尼日利亚，水痘主要影响成年人，部分由性活动驱动；儿童病例是由密切接触驱动的，动物暴露,和VZV共感染。
