Abstract：
We studied the effect of enteral administration of GABA on the gastric mucosa in male Wistar rats (n=47) with modeled metabolic stress (food deprivation for 9 days with free access to water). The relative weights of the adrenal glands and thymus were determined, and histological examination of the stomach was performed. In control rats, modeling the metabolic stress was accompanied by the development of erosive damage to the gastric mucosa related to blood supply disturbances. Administration of GABA prevented erosions and exhibited a pronounced gastroprotective effect. Thus, administration of GABA can be a promising method for the prevention and treatment of erosive gastric lesions associated with metabolic stress.
摘要：
我们研究了肠内施用GABA对具有模型代谢应激（食物剥夺9天，自由饮水）的雄性Wistar大鼠（n=47）胃粘膜的影响。确定肾上腺和胸腺的相对重量，并对胃进行组织学检查。在对照大鼠中，建模代谢应激伴随着与血液供应障碍相关的胃粘膜糜烂损伤的发展。施用GABA可预防糜烂并表现出明显的胃保护作用。因此，给予GABA可以是预防和治疗与代谢应激相关的糜烂性胃病变的有希望的方法。
