{Reference Type}: Journal Article
{Title}: Gastroprotective Effect of GABA in Metabolic Stress.
{Author}: Tropskaya NS;Gurman YV;Popova TS;Kanibolotsky AA;
{Journal}: Bull Exp Biol Med
{Volume}: 177
{Issue}: 3
{Year}: 2024 Jul 10
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06178-w
{Abstract}: We studied the effect of enteral administration of GABA on the gastric mucosa in male Wistar rats (n=47) with modeled metabolic stress (food deprivation for 9 days with free access to water). The relative weights of the adrenal glands and thymus were determined, and histological examination of the stomach was performed. In control rats, modeling the metabolic stress was accompanied by the development of erosive damage to the gastric mucosa related to blood supply disturbances. Administration of GABA prevented erosions and exhibited a pronounced gastroprotective effect. Thus, administration of GABA can be a promising method for the prevention and treatment of erosive gastric lesions associated with metabolic stress.