PDF(Pubmed)
Abstract：
BACKGROUND: Tinnitus is the phantom perception of sound in the ears or head which may result from inflammation of the auditory pathway. A healthy diet consisting of a range of vitamins and minerals may be protective against tinnitus. This study aims to determine the association between intakes of dietary vitamins and minerals and the prevalence and incidence of tinnitus over 10 years.
METHODS: In this longitudinal cohort study of 2947 participants (aged ≥ 50 years), 935 (32%) cases of tinnitus were identified and included in prevalence analyses. The remaining 2012 participants were followed to establish 10-year incidence of tinnitus. A validated semi-quantitative food frequency questionnaire was used to determine intakes of dietary vitamins and minerals.
RESULTS: No significant associations with tinnitus prevalence were found. However, iron and zinc were significantly associated with incident tinnitus. There was a 44% (multivariate-adjusted HR: 1.44, 95% CI: 1.07-1.93) increased risk of developing incident tinnitus over 10 years with lower zinc intakes and a 35% increased risk with lower iron intakes (multivariate-adjusted HR: 1.35, 95% CI: 1.00-1.80).
CONCLUSIONS: Higher intakes of zinc and iron were significantly associated with lower tinnitus risk. Due to a lack of comparable high-quality data, future research studies should include robust study designs.
METHODS: In this longitudinal cohort study of 2947 participants (aged ≥ 50 years), 935 (32%) cases of tinnitus were identified and included in prevalence analyses. The remaining 2012 participants were followed to establish 10-year incidence of tinnitus. A validated semi-quantitative food frequency questionnaire was used to determine intakes of dietary vitamins and minerals.
RESULTS: No significant associations with tinnitus prevalence were found. However, iron and zinc were significantly associated with incident tinnitus. There was a 44% (multivariate-adjusted HR: 1.44, 95% CI: 1.07-1.93) increased risk of developing incident tinnitus over 10 years with lower zinc intakes and a 35% increased risk with lower iron intakes (multivariate-adjusted HR: 1.35, 95% CI: 1.00-1.80).
CONCLUSIONS: Higher intakes of zinc and iron were significantly associated with lower tinnitus risk. Due to a lack of comparable high-quality data, future research studies should include robust study designs.
摘要：
背景：耳鸣是耳朵或头部声音的幻影感知，可能是由听觉通路的炎症引起的。由一系列维生素和矿物质组成的健康饮食可以预防耳鸣。这项研究旨在确定膳食维生素和矿物质的摄入量与10年以上耳鸣的患病率和发病率之间的关系。
方法：在这项针对2947名参与者（年龄≥50岁）的纵向队列研究中，确定了935例（32％）耳鸣病例，并将其纳入患病率分析。对其余的2012年参与者进行随访，以确定10年的耳鸣发生率。使用经过验证的半定量食物频率问卷来确定膳食维生素和矿物质的摄入量。
结果：未发现与耳鸣患病率有显著关联。然而,铁和锌与耳鸣事件显著相关。在锌摄入量较低的情况下，10年内发生耳鸣的风险增加了44％（多变量调整后的HR：1.44，95％CI：1.07-1.93），铁摄入量较低的风险增加了35％（多变量调整后的HR：1.35，95％CI：1.00-1.80）。
结论：较高的锌和铁摄入量与较低的耳鸣风险显著相关。由于缺乏可比较的高质量数据，未来的研究应该包括健壮的研究设计。
方法：在这项针对2947名参与者（年龄≥50岁）的纵向队列研究中，确定了935例（32％）耳鸣病例，并将其纳入患病率分析。对其余的2012年参与者进行随访，以确定10年的耳鸣发生率。使用经过验证的半定量食物频率问卷来确定膳食维生素和矿物质的摄入量。
结果：未发现与耳鸣患病率有显著关联。然而,铁和锌与耳鸣事件显著相关。在锌摄入量较低的情况下，10年内发生耳鸣的风险增加了44％（多变量调整后的HR：1.44，95％CI：1.07-1.93），铁摄入量较低的风险增加了35％（多变量调整后的HR：1.35，95％CI：1.00-1.80）。
结论：较高的锌和铁摄入量与较低的耳鸣风险显著相关。由于缺乏可比较的高质量数据，未来的研究应该包括健壮的研究设计。
