PDF(Pubmed)
Abstract：
BACKGROUND: For the study of quantitative and qualitative muscle parameters, ultrasound and bioelectric impedance analysis are reliable, non-invasive, and reproducible. The aim of this study was to test the combined role of those techniques for the diagnosis of sarcopenia in a population of hospitalized older males and females.
METHODS: A total of 70 subjects were recruited, including 10 healthy adults and 60 hospitalized elderly patients with a good level of independence and cooperation, with and without sarcopenia. The rectus femoris cross-sectional area (CSA), thickness, echogenicity, and compressibility were measured with ultrasound echography. The phase angles (PhAs) and skeletal muscle mass were calculated by bioimpedence analysis. The muscle quality index (MQI) was calculated as the product of CSA and PhA.
RESULTS: Muscle compressibility was greater and PhA was lower in sarcopenic when compared with non-sarcopenic subjects. The threshold values for sarcopenia diagnosis in both sexes of CSA, of PhA, and of the MQI were identified. The obtained CSA values showed an AUC of 0.852 for women and 0.867 for men, PhA of 0.792 in women and 0.898 in men, while MQI was 0.900 for women and 0.969 for men.
CONCLUSIONS: The newly calculated cut-off values of CSA, PhA, and MQI predicted the presence of sarcopenia with good sensitivity and specificity values. The use of the MQI proved to be more promising than the separate use of CSA and PhA in both male and female subjects.
METHODS: A total of 70 subjects were recruited, including 10 healthy adults and 60 hospitalized elderly patients with a good level of independence and cooperation, with and without sarcopenia. The rectus femoris cross-sectional area (CSA), thickness, echogenicity, and compressibility were measured with ultrasound echography. The phase angles (PhAs) and skeletal muscle mass were calculated by bioimpedence analysis. The muscle quality index (MQI) was calculated as the product of CSA and PhA.
RESULTS: Muscle compressibility was greater and PhA was lower in sarcopenic when compared with non-sarcopenic subjects. The threshold values for sarcopenia diagnosis in both sexes of CSA, of PhA, and of the MQI were identified. The obtained CSA values showed an AUC of 0.852 for women and 0.867 for men, PhA of 0.792 in women and 0.898 in men, while MQI was 0.900 for women and 0.969 for men.
CONCLUSIONS: The newly calculated cut-off values of CSA, PhA, and MQI predicted the presence of sarcopenia with good sensitivity and specificity values. The use of the MQI proved to be more promising than the separate use of CSA and PhA in both male and female subjects.
摘要：
背景：对于定量和定性肌肉参数的研究，超声和生物电阻抗分析是可靠的，非侵入性，和可重复的。这项研究的目的是测试这些技术在住院的老年男性和女性人群中诊断肌少症的综合作用。
方法：共招募70名受试者，包括10名健康成年人和60名住院老年患者，他们具有良好的独立和合作水平，有和没有肌肉减少症。股直肌横截面积(CSA)，厚度,回声,和可压缩性用超声回波描记术测量。通过生物阻抗分析计算相位角（PhAs）和骨骼肌质量。肌肉质量指数(MQI)计算为CSA和PhA的乘积。
结果：与非肌少症患者相比，肌少症患者的肌肉可压缩性更大，PhA更低。CSA男女诊断肌少症的阈值，PhA,并确定了MQI。获得的CSA值显示女性的AUC为0.852，男性为0.867，女性PhA为0.792，男性为0.898，而女性MQI为0.900，男性为0.969。
结论：新计算的CSA的截止值，PhA,MQI预测肌少症的存在具有良好的敏感性和特异性值。事实证明，在男性和女性受试者中，使用MQI比分别使用CSA和PhA更有希望。
方法：共招募70名受试者，包括10名健康成年人和60名住院老年患者，他们具有良好的独立和合作水平，有和没有肌肉减少症。股直肌横截面积(CSA)，厚度,回声,和可压缩性用超声回波描记术测量。通过生物阻抗分析计算相位角（PhAs）和骨骼肌质量。肌肉质量指数(MQI)计算为CSA和PhA的乘积。
结果：与非肌少症患者相比，肌少症患者的肌肉可压缩性更大，PhA更低。CSA男女诊断肌少症的阈值，PhA,并确定了MQI。获得的CSA值显示女性的AUC为0.852，男性为0.867，女性PhA为0.792，男性为0.898，而女性MQI为0.900，男性为0.969。
结论：新计算的CSA的截止值，PhA,MQI预测肌少症的存在具有良好的敏感性和特异性值。事实证明，在男性和女性受试者中，使用MQI比分别使用CSA和PhA更有希望。
