背景:衰弱是一种老年综合征,其特征是由于生物储备减少,对内在和外在应激源的脆弱性增加。肌肉超声(US)是评估老年人肌肉数量的有效且可靠的方法。该研究旨在研究虚弱定义与US衍生的肌肉参数之间的关系。
方法:我们对三级医院的2型糖尿病门诊患者进行了一项横断面研究,所有参与者都接受了全面的老年评估.对于脆弱评估,油炸脆弱表型(FFP),临床虚弱量表(CFS),并进行了埃德蒙顿衰弱量表(EFS)。美国肌肉测量包括腓肠肌(GM)肌肉厚度,GM分册长度,通用汽车的悬念角度,股直肌(RF)肌肉厚度,股直肌横截面积(RFCSA),腹直肌(RA)肌肉厚度,外部倾斜(EO)肌肉厚度,内部倾斜(IO)肌肉厚度,和横腹(TA)肌肉厚度。
结果:总而言之,373名参与者被纳入研究。参与者的平均年龄为72.7±5.9岁,其中64.6%是女性。根据FFP,18.2%的参与者生活脆弱,其中56%的人处于虚弱状态;根据CFS的数据,其中57.4%的人生活虚弱;其中25.2%的人生活虚弱,根据EFS,其中20.6%的人处于虚弱状态。FFP,CFS,EFS评分与GM的肌肉厚度有关,射频,RA,GM的分册长度,以及GM和RFCSA的谴责角度。特别是,通用汽车的悬念角度,射频肌肉厚度,和RFCSA与虚弱风险增加相关。除了GM的肌肉厚度,射频,RA,GM的分册长度,通用汽车的悬念角度,和RFCSA对预测虚弱的存在具有重要意义。
结论:美国衍生的区域肌肉测量与虚弱定义相关(在两个物理,累积赤字,和多维模型)在糖尿病老年人群中。
BACKGROUND: Frailty is a geriatric syndrome that is characterized by increased vulnerability to intrinsic and extrinsic stressors due to decreased biologic reserves. Muscle ultrasound (US) is a valid and reliable method for assessing muscle quantity in older adults. The study aims to examine the relationship between frailty definitions and US-derived muscle parameters.
METHODS: We conducted a cross-sectional study with type 2 diabetes mellitus outpatients in a tertiary hospital, and all participants underwent a comprehensive geriatric assessment. For frailty assessment, the Fried Frailty Phenotype (FFP), the Clinical Frailty Scale (CFS), and the Edmonton Frailty Scale (EFS) were performed. Muscle US measurements included Gastrocnemius Medialis (GM) muscle thickness, GM fascicle length, GM pennation angle, Rectus Femoris (RF) muscle thickness, Rectus Femoris cross-sectional area (RFCSA), Rectus Abdominis (RA) muscle thickness, External Oblique (EO) muscle thickness, Internal Oblique (IO) muscle thickness, and Transverse Abdominis (TA) muscle thickness.
RESULTS: In all, 373 participants were included in the study. The median age of participants was 72.7 ± 5.9 years, and 64.6% of them were female. According to the FFP, 18.2% of the participants were living with frailty, 56% of them were pre-frail; 57.4% of them were living with frailty according to the CFS; 25.2% of them were living with frailty, and 20.6% of them were pre-frail according to the EFS. The FFP, CFS, and EFS scores were related to muscle thickness of GM, RF, and RA, fascicle length of GM, and pennation angle of GM and RFCSA. Particularly, GM pennation angle, RF muscle thickness, and RFCSA were associated with an increased risk of frailty. Besides muscle thickness of GM, RF, and RA, fascicle length of GM, pennation angle of GM, and RFCSA were significant for predicting the presence of frailty.
CONCLUSIONS: US-derived regional muscle measurements are associated with frailty definitions (in both physical, cumulative deficit, and multidimensional models) in a diabetic geriatric population.