PDF(Pubmed)
Abstract：
UNASSIGNED: We determined interblink corneal surface-temperature decline and tear-film evaporation rates of localized tear breakup cold regions (LCRs) and localized tear unbroken warm regions (LWRs) of the corneal surface, as well as that of the overall average corneal surface.
UNASSIGNED: Each subject underwent 4 inter-day visits where the interblink corneal surface-temperature history of the right eye was measured using a FLIR A655sc infrared thermographer. Corneal surface temperature history was analyzed to determine the overall, LCR, and LWR temperature-decline rates. Evaporation rates of LCR and LWR regions were determined from the measured LCR and LWR temperature data using the physical model of Dursch et al.
UNASSIGNED: Twenty subjects completed the study. Mean (SD) difference of LCR temperature-decline rate was -0.08 (0.07)°C/s faster than LWR (P < 0.0001). Similarly, evaporation rates of LCR and LWR were statistically different (P < 0.0001). At ambient temperature, mean LCR and LWR evaporation rates were 76% and 27% of pure water evaporation flux, respectively. There was no statistically significant difference between the inter-day measured temperature-decline rates and the interblink starting temperature.
UNASSIGNED: Significant differences in corneal temperature-decline rate and evaporation rate between LCR and LWR were quantified using infrared thermography. In agreement with literature, LCRs and LWRs correlate directly with fluorescein break-up areas and unbroken tear areas, respectively. Because lipid-evaporation protection is diminished in breakup areas, higher local evaporation rates and faster local cooling rates occur in LCRs relative to LWRs. Our results confirm this phenomenon clinically for the first time.
UNASSIGNED: Each subject underwent 4 inter-day visits where the interblink corneal surface-temperature history of the right eye was measured using a FLIR A655sc infrared thermographer. Corneal surface temperature history was analyzed to determine the overall, LCR, and LWR temperature-decline rates. Evaporation rates of LCR and LWR regions were determined from the measured LCR and LWR temperature data using the physical model of Dursch et al.
UNASSIGNED: Twenty subjects completed the study. Mean (SD) difference of LCR temperature-decline rate was -0.08 (0.07)°C/s faster than LWR (P < 0.0001). Similarly, evaporation rates of LCR and LWR were statistically different (P < 0.0001). At ambient temperature, mean LCR and LWR evaporation rates were 76% and 27% of pure water evaporation flux, respectively. There was no statistically significant difference between the inter-day measured temperature-decline rates and the interblink starting temperature.
UNASSIGNED: Significant differences in corneal temperature-decline rate and evaporation rate between LCR and LWR were quantified using infrared thermography. In agreement with literature, LCRs and LWRs correlate directly with fluorescein break-up areas and unbroken tear areas, respectively. Because lipid-evaporation protection is diminished in breakup areas, higher local evaporation rates and faster local cooling rates occur in LCRs relative to LWRs. Our results confirm this phenomenon clinically for the first time.
摘要：
■我们确定了角膜表面的局部泪液破裂冷区（LCR）和局部泪液未破裂暖区（LWR）的眨眼间角膜表面温度下降和泪膜蒸发率，以及整个平均角膜表面。
■每位受试者进行4次日间访问，其中使用FLIRA655sc红外热像仪测量右眼的眨眼间角膜表面温度历史。角膜表面温度历史进行了分析，以确定整体，LCR,和LWR温度下降率。使用Dursch等人的物理模型从测量的LCR和LWR温度数据确定LCR和LWR区域的蒸发速率。
■20名受试者完成了研究。LCR温度下降速率的平均值（SD）比LWR快-0.08（0.07）°C/s（P<0.0001）。同样，LCR和LWR的蒸发率差异有统计学意义(P<0.0001)。在环境温度下，平均LCR和LWR蒸发率分别为纯水蒸发通量的76%和27%，分别。日间测量的温度下降率与闪烁起始温度之间没有统计学上的显着差异。
■使用红外热成像技术对LCR和LWR之间的角膜温度下降速率和蒸发速率的显着差异进行了量化。与文学一致，LCR和LWR与荧光素破裂区域和未破裂的泪液区域直接相关，分别。因为分解区域的脂质蒸发保护作用减弱，相对于LWR，LCR中出现更高的局部蒸发速率和更快的局部冷却速率。我们的结果首次在临床上证实了这一现象。
■每位受试者进行4次日间访问，其中使用FLIRA655sc红外热像仪测量右眼的眨眼间角膜表面温度历史。角膜表面温度历史进行了分析，以确定整体，LCR,和LWR温度下降率。使用Dursch等人的物理模型从测量的LCR和LWR温度数据确定LCR和LWR区域的蒸发速率。
■20名受试者完成了研究。LCR温度下降速率的平均值（SD）比LWR快-0.08（0.07）°C/s（P<0.0001）。同样，LCR和LWR的蒸发率差异有统计学意义(P<0.0001)。在环境温度下，平均LCR和LWR蒸发率分别为纯水蒸发通量的76%和27%，分别。日间测量的温度下降率与闪烁起始温度之间没有统计学上的显着差异。
■使用红外热成像技术对LCR和LWR之间的角膜温度下降速率和蒸发速率的显着差异进行了量化。与文学一致，LCR和LWR与荧光素破裂区域和未破裂的泪液区域直接相关，分别。因为分解区域的脂质蒸发保护作用减弱，相对于LWR，LCR中出现更高的局部蒸发速率和更快的局部冷却速率。我们的结果首次在临床上证实了这一现象。
