Abstract：
OBJECTIVE: The prevalence of peripheral artery disease is growing, with millions of people globally suffering its end-stage manifestation, chronic limb-threatening ischemia (CLTI). Revascularization procedures like lower extremity bypass play a vital role in limb salvage but optimal medical therapy is essential for maximizing the benefit of these procedures and reducing long-term risks of cardiovascular and limb-related events.
RESULTS: Patients with PAD who undergo lower extremity bypass warrant a comprehensive approach to risk factor modification for both primary and secondary prevention of cardiovascular and limb-related complications. This includes appropriate use of high-intensity statins, smoking cessation, and management of hypertension and diabetes. Additionally, antiplatelet therapy is indicated for all patients with CLTI and additional treatment with low-dose anticoagulation may also be beneficial.
CONCLUSIONS: Optimal medical therapy is essential for optimizing outcomes in patients with PAD undergoing lower extremity bypass.
RESULTS: Patients with PAD who undergo lower extremity bypass warrant a comprehensive approach to risk factor modification for both primary and secondary prevention of cardiovascular and limb-related complications. This includes appropriate use of high-intensity statins, smoking cessation, and management of hypertension and diabetes. Additionally, antiplatelet therapy is indicated for all patients with CLTI and additional treatment with low-dose anticoagulation may also be beneficial.
CONCLUSIONS: Optimal medical therapy is essential for optimizing outcomes in patients with PAD undergoing lower extremity bypass.
摘要：
目的：外周动脉疾病的患病率正在上升，全球数百万人遭受其最后阶段的表现，慢性威胁肢体缺血（CLTI）。下肢搭桥等血运重建手术在保肢中起着至关重要的作用，但最佳的药物治疗对于最大化这些手术的益处和降低心血管和肢体相关事件的长期风险至关重要。
结果：接受下肢搭桥手术的PAD患者需要采取全面的方法来改变危险因素，以进行心血管和肢体相关并发症的一级和二级预防。这包括适当使用高强度他汀类药物，戒烟,以及高血压和糖尿病的管理。此外,抗血小板治疗适用于所有CLTI患者,低剂量抗凝治疗也可能有益.
结论：最佳药物治疗对于优化下肢旁路手术患者的预后至关重要。
结果：接受下肢搭桥手术的PAD患者需要采取全面的方法来改变危险因素，以进行心血管和肢体相关并发症的一级和二级预防。这包括适当使用高强度他汀类药物，戒烟,以及高血压和糖尿病的管理。此外,抗血小板治疗适用于所有CLTI患者,低剂量抗凝治疗也可能有益.
结论：最佳药物治疗对于优化下肢旁路手术患者的预后至关重要。
