%0 Journal Article
%T The importance of optimal medical therapy in patients undergoing lower extremity bypass.
%A Gomez-Sanchez CM
%A Conte MS
%J Curr Opin Cardiol
%V 39
%N 5
%D 2024 Sep 1
%M 39110079
%F 2.108
%R 10.1097/HCO.0000000000001157
%X <B>OBJECTIVE: </B>The prevalence of peripheral artery disease is growing, with millions of people globally suffering its end-stage manifestation, chronic limb-threatening ischemia (CLTI). Revascularization procedures like lower extremity bypass play a vital role in limb salvage but optimal medical therapy is essential for maximizing the benefit of these procedures and reducing long-term risks of cardiovascular and limb-related events.<BR><B>RESULTS: </B>Patients with PAD who undergo lower extremity bypass warrant a comprehensive approach to risk factor modification for both primary and secondary prevention of cardiovascular and limb-related complications. This includes appropriate use of high-intensity statins, smoking cessation, and management of hypertension and diabetes. Additionally, antiplatelet therapy is indicated for all patients with CLTI and additional treatment with low-dose anticoagulation may also be beneficial.<BR><B>CONCLUSIONS: </B>Optimal medical therapy is essential for optimizing outcomes in patients with PAD undergoing lower extremity bypass.