{Reference Type}: Journal Article
{Title}: The importance of optimal medical therapy in patients undergoing lower extremity bypass.
{Author}: Gomez-Sanchez CM;Conte MS;
{Journal}: Curr Opin Cardiol
{Volume}: 39
{Issue}: 5
{Year}: 2024 Sep 1
{Factor}: 2.108
{DOI}: 10.1097/HCO.0000000000001157
{Abstract}: <B>OBJECTIVE: </B>The prevalence of peripheral artery disease is growing, with millions of people globally suffering its end-stage manifestation, chronic limb-threatening ischemia (CLTI). Revascularization procedures like lower extremity bypass play a vital role in limb salvage but optimal medical therapy is essential for maximizing the benefit of these procedures and reducing long-term risks of cardiovascular and limb-related events.<BR><B>RESULTS: </B>Patients with PAD who undergo lower extremity bypass warrant a comprehensive approach to risk factor modification for both primary and secondary prevention of cardiovascular and limb-related complications. This includes appropriate use of high-intensity statins, smoking cessation, and management of hypertension and diabetes. Additionally, antiplatelet therapy is indicated for all patients with CLTI and additional treatment with low-dose anticoagulation may also be beneficial.<BR><B>CONCLUSIONS: </B>Optimal medical therapy is essential for optimizing outcomes in patients with PAD undergoing lower extremity bypass.