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Abstract：
Enantioselective halolactonizations of sterically less hindered alkenoic acid substrates without substituents on the carbon-carbon double bond have remained a formidable challenge. To address this limitation, we report herein the asymmetric bromolactonization of 5-hexenoic acid derivatives catalyzed by a BINOL-derived chiral bifunctional sulfide.
摘要：
在碳-碳双键上没有取代基的空间位阻较小的链烯酸底物的对映体选择性卤代内酯化仍然是一个艰巨的挑战。为了解决这个限制，我们在此报道了由BINOL衍生的手性双官能硫化物催化的5-己烯酸衍生物的不对称溴内酯化。
