现代纳米医学将多模式治疗整合到一个单一的配方中,提供创新的癌症治疗选择。纳米片作为载体,改变溶解度,生物分布,和药用化合物的有效性,导致更有效的癌症治疗和减少副作用。氟化氧化石墨烯(FGO)纳米片的无毒性质及其在药物递送中的潜在应用,医学诊断,生物医学将它们与其他人区分开来。利用Lissachatinafulica蜗牛粘液(LfSM)的独特特性,开发了FGO纳米片以揭示新颖的特性。因此,LfSM被用来制造无毒的,环保,和持久的FGO纳米片。紫外-可见(UV-vis)光谱显示出在235nm处的显著吸收峰。合成的FGO纳米片的表征包括X射线衍射(XRD),傅里叶变换红外光谱(FTIR),拉曼,扫描电子显微镜(SEM),X射线光电子能谱(XPS),高分辨率透射电子显微镜(HR-TEM),和原子力显微镜(AFM)分析。抗菌活性数据证明了对大肠杆菌的广谱抗菌作用,枯草芽孢杆菌,肺炎克雷伯菌,还有铜绿假单胞菌.LfSM-FGO纳米片对胰腺癌细胞系(PANC1)的细胞毒性功效在低浓度下显示出有希望的结果。该研究表明,由LfSM制成的FGO纳米片可以作为未来生物医学应用的替代因素。
The modern nanomedicine incorporates the multimodal treatments into a single formulation, offering innovative cancer therapy options. Nanosheets function as carriers, altering the solubility, biodistribution, and effectiveness of medicinal compounds, resulting in more efficient cancer treatments and reduced side effects. The non-toxic nature of fluorinated graphene oxide (FGO) nanosheets and their potential applications in medication delivery, medical diagnostics, and biomedicine distinguish them from others. Leveraging the unique properties of Lissachatina fulica snail mucus (LfSM), FGO nanosheets were developed to reveal the novel characteristics. Consequently, LfSM was utilized to create non-toxic, environmentally friendly, and long-lasting FGO nanosheets. Ultraviolet-visible (UV-vis) spectroscopy revealed a prominent absorbance peak at 235 nm. The characterization of the synthesized FGO nanosheets involved X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), high-resolution transmission electron microscopy (HR-TEM), and atomic force microscopy (AFM) analyses. The antimicrobial activity data demonstrated a broad spectrum of antibacterial effects against Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, and Pseudomonas aeruginosa. The cytotoxicity efficacy of LfSM-FGO nanosheets against pancreatic cancer cell line (PANC1) showed promising results at low concentrations. The study suggests that FGO nanosheets made from LfSM could serve as alternate factors for in biomedical applications in the future.