小鼠胚胎干细胞中的氧化还原异质性使细胞命运决定个体化。
关键词: H3K4me3 epigenome Nrf2 signaling Wnt signaling pathway cell fate decision embryonic stem cells mesendoderm neuroectoderm reactive oxygen species redox stem cell heterogeneity
Mesh : Animals Mice Oxidation-Reduction Mouse Embryonic Stem Cells / metabolism cytology Cell Differentiation / physiology Reactive Oxygen Species / metabolism Wnt Signaling Pathway Mitochondria / metabolism NF-E2-Related Factor 2 / metabolism Histones / metabolism Cell Lineage Mesoderm / cytology metabolism
来 源:
DOI:10.1016/j.devcel.2024.07.008
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