Abstract：
Heat stress from varicocele can heighten oxidative stress in the testes, impacting sperm function and male fertility. Antioxidant therapy is explored as a remedy for varicocele, while dietary factors like processed foods, sugar, and saturated fats correlate with male infertility. Advanced glycation end products (AGEs), generated through glycation processes, can provoke oxidative stress, inflammation, and adverse health consequences. Alpha-lipoic acid (ALA), a versatile antioxidant, may alleviate oxidative stress and counteract the impact of AGEs, potentially by enhancing glucose reabsorption. Alagebrium chloride (ALT711), an anti-AGE compound, exhibits promise in cardiovascular disease by disrupting AGE cross-links. This study investigates the effects of ALA and ALT-711 on testicular function in varicocele and AGEs animal models. Both AGE and varicocele were found to alter the natural trends, leading to abnormal patterns in sperm parameters, testicular functional tests, as well as the expression of CML, RAGE, and TNF-α proteins. However, the administration of ALA or ALT711 helped mitigate these effects. While ALA demonstrated a slightly greater overall benefit compared to ALT, the difference was not statistically significant.
摘要：
精索静脉曲张的热应激可以增加睾丸的氧化应激，影响精子功能和男性生育能力。抗氧化治疗是精索静脉曲张的一种治疗方法，虽然饮食因素像加工食品，糖,饱和脂肪与男性不育有关。晚期糖基化终产物（AGEs），通过糖化过程产生，会引起氧化应激，炎症,和不利的健康后果。α-硫辛酸(ALA),一种多功能的抗氧化剂，可以缓解氧化应激并抵消AGEs的影响，可能通过增强葡萄糖的重吸收。氯化铝（ALT711），抗AGE化合物,通过破坏AGE交联在心血管疾病中表现出希望。这项研究调查了ALA和ALT-711对精索静脉曲张和AGEs动物模型睾丸功能的影响。发现年龄和精索静脉曲张都改变了自然趋势，导致精子参数的异常模式，睾丸功能测试,以及CML的表达，愤怒,和TNF-α蛋白。然而,ALA或ALT711的给药有助于减轻这些影响.虽然与ALT相比，ALA显示出略大的总体益处，差异无统计学意义。
