PDF(Pubmed)
Abstract：
Insufficient sleep duration may lead to a series of immune dysfunctions. One of the factors influencing this effect could be physical activity (PA). The study aimed to assess the impact of deprivation of sleep (DS) on selected inflammatory parameters. Seventy-seven participants completed the protocol consisting of polysomnography (PSG) conducted in a sleep laboratory and DS, monitored with an actigraph. PA was assessed with actigraphy, which categorized participants as active or inactive. White blood cells (WBC) values negatively correlated with sleep efficiency based on sleep diaries and PSG parameters (total sleep time, sleep efficiency, and REM duration), but regression analysis showed that WBC depends only on the sleep diary parameter. Granulocytes (GRA) positively correlated with REM latency, and negatively with sleep efficiency. After DS, all participants exhibited an elevated GRA count. The number of WBC and GRA increased also in the active group; inactive participants showed no changes in inflammatory parameters. The overall number of WBC depends primarily on the quality of sleep over a period of several days. Under the influence of sleep deprivation, the number of GRA increases, but the number of leukocytes depends on the level of physical activity during DS.
摘要：
睡眠持续时间不足可能导致一系列免疫功能障碍。影响这种影响的因素之一可能是身体活动（PA）。该研究旨在评估剥夺睡眠（DS）对选定炎症参数的影响。77名参与者完成了由睡眠实验室和DS进行的多导睡眠图（PSG）组成的协议。用活动记录仪监测。PA用肌动描记术评估，将参与者分为活跃或不活跃。根据睡眠日记和PSG参数，白细胞（WBC）值与睡眠效率呈负相关（总睡眠时间，睡眠效率，和REM持续时间)，但回归分析表明，白细胞仅取决于睡眠日记参数。粒细胞（GRA）与REM潜伏期呈正相关，对睡眠效率产生负面影响。DS之后,所有参与者的GRA计数均升高.WBC和GRA的数量在活动组中也增加;不活动的参与者显示炎症参数没有变化。白细胞总数主要取决于几天内的睡眠质量。在睡眠剥夺的影响下，GRA的数量增加，但是白细胞的数量取决于DS期间的身体活动水平。
