PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate the incidence rate, clinical characteristics across different age groups, antimicrobial susceptibility, and outcomes of Elizabethkingia meningoseptica (E. meningoseptica) infections.
METHODS: A retrospective analysis was carried out to include 66 cases with confirmed E. meningoseptica cultures from sterile samples between January 2014 and June 2022 at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia.
RESULTS: A total of 66 cases were identified, with an incidence rate of 0.3 per 1000 admissions. Most cases were hospital-acquired (80.3%), primarily in critical care areas. All patients had underlying diseases, with respiratory (40.9%) and cardiovascular (39.4%) diseases being the most common. Minocycline showed the highest susceptibility (96.0%), followed by trimethoprim/sulfamethoxazole (77.0%), whereas tobramycin and colistin were fully resistant. The in-hospital mortality rate was 34.8%, whereas the 28-day mortality rate was 22.7%. Clinical characteristics across age groups showed a higher prevalence of cardiovascular disease in pediatrics than in adults, whereas exposure to mechanical ventilation, immunosuppressive therapy, previous infection, anemia, and in-hospital mortality were reported more frequently in adults (p<0.05).
CONCLUSIONS: Our study provides valuable insights into E. meningoseptica infection in Saudi Arabia, emphasizing the importance of robust infection control measures. Incidence and mortality rates align with global trends. Variations in clinical characteristics across age groups highlight the importance of tailored treatments based on patient demographics and underlying comorbidities.
METHODS: A retrospective analysis was carried out to include 66 cases with confirmed E. meningoseptica cultures from sterile samples between January 2014 and June 2022 at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia.
RESULTS: A total of 66 cases were identified, with an incidence rate of 0.3 per 1000 admissions. Most cases were hospital-acquired (80.3%), primarily in critical care areas. All patients had underlying diseases, with respiratory (40.9%) and cardiovascular (39.4%) diseases being the most common. Minocycline showed the highest susceptibility (96.0%), followed by trimethoprim/sulfamethoxazole (77.0%), whereas tobramycin and colistin were fully resistant. The in-hospital mortality rate was 34.8%, whereas the 28-day mortality rate was 22.7%. Clinical characteristics across age groups showed a higher prevalence of cardiovascular disease in pediatrics than in adults, whereas exposure to mechanical ventilation, immunosuppressive therapy, previous infection, anemia, and in-hospital mortality were reported more frequently in adults (p<0.05).
CONCLUSIONS: Our study provides valuable insights into E. meningoseptica infection in Saudi Arabia, emphasizing the importance of robust infection control measures. Incidence and mortality rates align with global trends. Variations in clinical characteristics across age groups highlight the importance of tailored treatments based on patient demographics and underlying comorbidities.
摘要：
目的：调查发病率，不同年龄段的临床特征，抗菌敏感性，和Elizabethkingia的结果（E.脑膜病）感染。
方法：对2014年1月至2022年6月在利雅得费萨尔国王专科医院和研究中心进行了回顾性分析，纳入了66例确诊的脑膜炎球菌培养物无菌样本。沙特阿拉伯。
结果：共确认66例，发病率为0.3/1000入院。大多数病例是医院获得的（80.3%），主要在重症监护领域。所有病人都有潜在的疾病,以呼吸系统疾病（40.9%）和心血管疾病（39.4%）最为常见。米诺环素敏感性最高（96.0%），其次是甲氧苄啶/磺胺甲恶唑（77.0%），而妥布霉素和粘菌素完全耐药。住院死亡率为34.8%,而28日死亡率为22.7%.不同年龄段的临床特征表明，儿科心血管疾病的患病率高于成人，而暴露于机械通气，免疫抑制治疗,以前的感染，贫血,和住院死亡率在成人中更常见(p<0.05).
结论：我们的研究提供了有关沙特阿拉伯脑膜感染的宝贵见解，强调强有力的感染控制措施的重要性。发病率和死亡率与全球趋势一致。不同年龄段的临床特征差异突出了基于患者人口统计学和潜在合并症的定制治疗的重要性。
方法：对2014年1月至2022年6月在利雅得费萨尔国王专科医院和研究中心进行了回顾性分析，纳入了66例确诊的脑膜炎球菌培养物无菌样本。沙特阿拉伯。
结果：共确认66例，发病率为0.3/1000入院。大多数病例是医院获得的（80.3%），主要在重症监护领域。所有病人都有潜在的疾病,以呼吸系统疾病（40.9%）和心血管疾病（39.4%）最为常见。米诺环素敏感性最高（96.0%），其次是甲氧苄啶/磺胺甲恶唑（77.0%），而妥布霉素和粘菌素完全耐药。住院死亡率为34.8%,而28日死亡率为22.7%.不同年龄段的临床特征表明，儿科心血管疾病的患病率高于成人，而暴露于机械通气，免疫抑制治疗,以前的感染，贫血,和住院死亡率在成人中更常见(p<0.05).
结论：我们的研究提供了有关沙特阿拉伯脑膜感染的宝贵见解，强调强有力的感染控制措施的重要性。发病率和死亡率与全球趋势一致。不同年龄段的临床特征差异突出了基于患者人口统计学和潜在合并症的定制治疗的重要性。
