Abstract：
Although three-dimensional visual training (3DVT) has been used for myopia intervention, its neural mechanisms remain largely unknown. In this study, visual function was examined before and after 3DVT, while resting-state EEG-fNIRS signals were recorded from 38 myopic participants. A graph theoretical analysis was applied to compute the neurovascular properties, including static brain networks (SBNs), dynamic brain networks (DBNs), and dynamic neurovascular coupling (DNC). Correlations between the changes in neurovascular properties and the changes in visual functions were calculated. After 3DVT, the local efficiency and node efficiency in the frontal lobes increased in the SBNs constructed from EEG δ -band; the global efficiency and node efficiency in the frontal-parietal lobes decreased in the DBNs variability constructed from EEG δ -band. For the DNC constructed with EEG α -band and oxyhemoglobin (HbO), the local efficiency decreased, for EEG α -band and deoxyhemoglobin (HbR), the node efficiency in the frontal-occipital lobes decreased. For the SBNs constructed from HbO, the functional connectivity (FC) between the frontal-occipital lobes increased. The DNC constructed between the FC of the frontal-parietal lobes from EEG β -band and the FC of the frontal-occipital lobes from HbO increased, and between the FC of the frontal-occipital lobes from EEG β -band and the FC of the inter-frontal lobes from HbR increased. The neurovascular properties were significantly correlated with the amplitude of accommodation and accommodative facility. The result indicated the positive effects of 3DVT on myopic participants, including improved efficiency of brain networks, increased FC of SBNs and DNC, and enhanced binocular accommodation functions.
摘要：
尽管三维视觉训练（3DVT）已用于近视干预，其神经机制在很大程度上仍然未知。在这项研究中,在3DVT前后检查视觉功能，同时记录了38例近视参与者的静息状态EEG-fNIRS信号。应用图论分析来计算神经血管特性，包括静态大脑网络(SBN)，动态大脑网络(DBN)，和动态神经血管耦合(DNC)。计算了神经血管特性的变化与视觉功能变化之间的相关性。3DVT后，在由EEGδ波段构建的SBN中，额叶的局部效率和节点效率增加；在由EEGδ波段构建的DBN变异性中，额顶叶的整体效率和节点效率降低。对于用EEGα波段和氧合血红蛋白(HbO)构建的DNC，当地效率下降，对于脑电图α波段和脱氧血红蛋白（HbR），额枕叶的节点效率降低。对于由HbO构建的SBN，额-枕叶之间的功能连接（FC）增加。在EEGβ波段的额顶叶的FC和HbO的额枕叶的FC之间构建的DNC增加，在EEGβ波段的额枕叶FC和HbR的额叶间FC之间增加。神经血管特性与调节和调节设施的幅度显着相关。结果表明3DVT对近视参与者的积极影响，包括提高大脑网络的效率，增加SBN和DNC的FC，和增强的双眼调节功能。
