METHODS: We included 272 patients who underwent amniotic membrane transplant for ocular surface pathology from January 2009 to December 2021. We retrospectively evaluated the medical data.
RESULTS: The male-to-female ratio of patients was 41/23. Mean age of the patients was 50 ± 23.6 years (range, 1-91 years). Indications consisted of ocular surface lesion excision surgery (n = 184; 66.7%), chemical injury (n = 25; 9.1%), persistent epithelial defect (n = 23; 8.3%), keratitis (n = 22; 8%), noninfectious corneal perforation (n = 9; 3.3%), bullous keratopathy (n = 9; 3.3%), and ocular cicatricial pemphigoid (n = 4; 1.4%). Single amniotic membrane transplant was applied to 236 patients (85.5%), and multiple transplant was applied to 40 patients (14.5%). We observed repeated amniotic membrane transplant rates and amniotic membrane degradation durations that were associated with primary disease (P = .005 and P < .001, respectively). Degradation time was shorter in cases of chemical burns and keratitis than in cases after ocular surface lesion excision. Amniotic membrane transplant indication rates were statistically different between the first 6 years and the last 6 years of the 12 years of data (P = .041). The frequency of amniotic membrane transplant application in microbial keratitis has increased substantially in the past 2 years.
CONCLUSIONS: Amniotic membrane is used as a biomaterial in various ocular surface diseases due to its anti-inflammatory, antimicrobial, and wound-healing properties. After transplant, the amniotic membrane, which is directly related to the inflam-matory processes of the primary disease, degrades gradually. There may be changes in the trend of amniotic membrane transplant, the indications of which are progressively expanding over time.
方法:我们纳入了2009年1月至2021年12月因眼表病理而接受羊膜移植的272例患者。我们回顾性评估了医疗数据。
结果:患者的男女比例为41/23。患者的平均年龄为50±23.6岁(范围,1-91岁)。适应症包括眼表病变切除手术(n=184;66.7%),化学伤害(n=25;9.1%),持续性上皮缺损(n=23;8.3%),角膜炎(n=22;8%),非感染性角膜穿孔(n=9;3.3%),大疱性角膜病变(n=9;3.3%),和眼瘢痕性类天疱疮(n=4;1.4%)。236例(85.5%)患者行羊膜移植,40例(14.5%)患者接受多次移植。我们观察到反复羊膜移植率和羊膜降解持续时间与原发疾病相关(分别为P=0.005和P<.001)。化学烧伤和角膜炎的降解时间比眼表病变切除后的降解时间短。羊膜移植适应症率在12年数据的前6年和后6年之间有统计学差异(P=.041)。在过去的两年中,羊膜移植在微生物性角膜炎中的应用频率已大大增加。
结论:羊膜由于其抗炎作用而被用作各种眼表疾病的生物材料,抗菌,和伤口愈合特性。移植后,羊膜,这与原发性疾病的炎症过程直接相关,逐渐退化。羊膜移植的趋势可能会发生变化,随着时间的推移,这些迹象正在逐步扩大。