Abstract：
OBJECTIVE: In this study, we aimed to define demographic data and trends in use of amniotic membrane transplant during the past decade at a tertiary eye center.
METHODS: We included 272 patients who underwent amniotic membrane transplant for ocular surface pathology from January 2009 to December 2021. We retrospectively evaluated the medical data.
RESULTS: The male-to-female ratio of patients was 41/23. Mean age of the patients was 50 ± 23.6 years (range, 1-91 years). Indications consisted of ocular surface lesion excision surgery (n = 184; 66.7%), chemical injury (n = 25; 9.1%), persistent epithelial defect (n = 23; 8.3%), keratitis (n = 22; 8%), noninfectious corneal perforation (n = 9; 3.3%), bullous keratopathy (n = 9; 3.3%), and ocular cicatricial pemphigoid (n = 4; 1.4%). Single amniotic membrane transplant was applied to 236 patients (85.5%), and multiple transplant was applied to 40 patients (14.5%). We observed repeated amniotic membrane transplant rates and amniotic membrane degradation durations that were associated with primary disease (P = .005 and P < .001, respectively). Degradation time was shorter in cases of chemical burns and keratitis than in cases after ocular surface lesion excision. Amniotic membrane transplant indication rates were statistically different between the first 6 years and the last 6 years of the 12 years of data (P = .041). The frequency of amniotic membrane transplant application in microbial keratitis has increased substantially in the past 2 years.
CONCLUSIONS: Amniotic membrane is used as a biomaterial in various ocular surface diseases due to its anti-inflammatory, antimicrobial, and wound-healing properties. After transplant, the amniotic membrane, which is directly related to the inflam-matory processes of the primary disease, degrades gradually. There may be changes in the trend of amniotic membrane transplant, the indications of which are progressively expanding over time.
METHODS: We included 272 patients who underwent amniotic membrane transplant for ocular surface pathology from January 2009 to December 2021. We retrospectively evaluated the medical data.
RESULTS: The male-to-female ratio of patients was 41/23. Mean age of the patients was 50 ± 23.6 years (range, 1-91 years). Indications consisted of ocular surface lesion excision surgery (n = 184; 66.7%), chemical injury (n = 25; 9.1%), persistent epithelial defect (n = 23; 8.3%), keratitis (n = 22; 8%), noninfectious corneal perforation (n = 9; 3.3%), bullous keratopathy (n = 9; 3.3%), and ocular cicatricial pemphigoid (n = 4; 1.4%). Single amniotic membrane transplant was applied to 236 patients (85.5%), and multiple transplant was applied to 40 patients (14.5%). We observed repeated amniotic membrane transplant rates and amniotic membrane degradation durations that were associated with primary disease (P = .005 and P < .001, respectively). Degradation time was shorter in cases of chemical burns and keratitis than in cases after ocular surface lesion excision. Amniotic membrane transplant indication rates were statistically different between the first 6 years and the last 6 years of the 12 years of data (P = .041). The frequency of amniotic membrane transplant application in microbial keratitis has increased substantially in the past 2 years.
CONCLUSIONS: Amniotic membrane is used as a biomaterial in various ocular surface diseases due to its anti-inflammatory, antimicrobial, and wound-healing properties. After transplant, the amniotic membrane, which is directly related to the inflam-matory processes of the primary disease, degrades gradually. There may be changes in the trend of amniotic membrane transplant, the indications of which are progressively expanding over time.
摘要：
目的：在本研究中，我们的目的是定义过去10年在三级眼科中心使用羊膜移植的人口统计学数据和趋势.
方法：我们纳入了2009年1月至2021年12月因眼表病理而接受羊膜移植的272例患者。我们回顾性评估了医疗数据。
结果：患者的男女比例为41/23。患者的平均年龄为50±23.6岁（范围，1-91岁）。适应症包括眼表病变切除手术（n=184；66.7％），化学伤害（n=25；9.1％），持续性上皮缺损（n=23；8.3％），角膜炎（n=22;8%），非感染性角膜穿孔（n=9;3.3％），大疱性角膜病变（n=9;3.3％），和眼瘢痕性类天疱疮（n=4；1.4％）。236例(85.5%)患者行羊膜移植,40例(14.5%)患者接受多次移植。我们观察到反复羊膜移植率和羊膜降解持续时间与原发疾病相关（分别为P=0.005和P<.001）。化学烧伤和角膜炎的降解时间比眼表病变切除后的降解时间短。羊膜移植适应症率在12年数据的前6年和后6年之间有统计学差异（P=.041）。在过去的两年中，羊膜移植在微生物性角膜炎中的应用频率已大大增加。
结论：羊膜由于其抗炎作用而被用作各种眼表疾病的生物材料，抗菌，和伤口愈合特性。移植后,羊膜，这与原发性疾病的炎症过程直接相关，逐渐退化。羊膜移植的趋势可能会发生变化，随着时间的推移，这些迹象正在逐步扩大。
方法：我们纳入了2009年1月至2021年12月因眼表病理而接受羊膜移植的272例患者。我们回顾性评估了医疗数据。
结果：患者的男女比例为41/23。患者的平均年龄为50±23.6岁（范围，1-91岁）。适应症包括眼表病变切除手术（n=184；66.7％），化学伤害（n=25；9.1％），持续性上皮缺损（n=23；8.3％），角膜炎（n=22;8%），非感染性角膜穿孔（n=9;3.3％），大疱性角膜病变（n=9;3.3％），和眼瘢痕性类天疱疮（n=4；1.4％）。236例(85.5%)患者行羊膜移植,40例(14.5%)患者接受多次移植。我们观察到反复羊膜移植率和羊膜降解持续时间与原发疾病相关（分别为P=0.005和P<.001）。化学烧伤和角膜炎的降解时间比眼表病变切除后的降解时间短。羊膜移植适应症率在12年数据的前6年和后6年之间有统计学差异（P=.041）。在过去的两年中，羊膜移植在微生物性角膜炎中的应用频率已大大增加。
结论：羊膜由于其抗炎作用而被用作各种眼表疾病的生物材料，抗菌，和伤口愈合特性。移植后,羊膜，这与原发性疾病的炎症过程直接相关，逐渐退化。羊膜移植的趋势可能会发生变化，随着时间的推移，这些迹象正在逐步扩大。
