PDF(Pubmed)
Abstract：
Viruses impose a significant public health burden globally, and one of the key elements in controlling their transmission is the ability to inactivate them using disinfectants. However, numerous challenges to inactivating foodborne viruses exist due to inherent viral characteristics (such as recalcitrance to commonly used inactivation agents) and external factors (such as improper cleaning before application of inactivation agent, improper contact time, etc.). Given the potential for improper application of disinfectants (such as shorter than recommended contact time, improper disinfectant concentration, etc.), understanding the performance of a disinfectant in the presence of an organic load is important. To accomplish this, the introduction of simulated organic loads is often used when studying the efficacy of a disinfectant against different viruses. However, the different types of simulated organic loads used in foodborne virus inactivation studies or their relative effects on inactivation have not been reviewed. The purpose of this review is to survey different simulated organic load formulations used in studying foodborne virus inactivation, as well as present and compare the influence of these different formulations on viral inactivation. The findings included in this review suggest that many simulated organic load formulations can reduce disinfectants\' efficacy against viruses. Based on the findings in this review, blood, particularly serum or feces, are among the most commonly used and efficacious forms of simulated organic load in many tests.
摘要：
病毒给全球造成了巨大的公共卫生负担，控制它们传播的关键因素之一是使用消毒剂灭活它们的能力。然而,由于固有的病毒特征（例如对常用灭活剂的顽抗）和外部因素（例如在应用灭活剂之前的不适当清洁，接触时间不当,等。).考虑到消毒剂应用不当的可能性(如接触时间短于推荐时间,消毒剂浓度不当，等。),了解消毒剂在有机负载存在下的性能很重要。要做到这一点，在研究消毒剂对不同病毒的功效时，经常使用模拟有机负荷的引入。然而,食源性病毒灭活研究中使用的不同类型的模拟有机载量及其对灭活的相对影响尚未进行审查。这篇综述的目的是调查用于研究食源性病毒灭活的不同模拟有机负荷制剂，以及介绍和比较这些不同制剂对病毒灭活的影响。这篇综述中的研究结果表明，许多模拟有机负荷制剂可以降低消毒剂对病毒的效力。根据这篇综述的发现，血,特别是血清或粪便，是许多测试中最常用和最有效的模拟有机负荷形式之一。
