PDF(Pubmed)
Abstract：
Human infections with Corynebacterium diphtheriae species complex (CdSC) bacteria were rare in French Guiana until 2016, when the number of cases diagnosed increased. We conducted an epidemiologic, multicenter, retrospective study of all human CdSC infections diagnosed in French Guiana during January 1, 2016-December 31, 2021. A total of 64 infectious episodes were observed in 60 patients; 61 infections were caused by C. diphtheriae and 3 by C. ulcerans. Estimated incidence increased from 0.7 cases/100,000 population in 2016 to 7.7 cases/100,000 population in 2021. The mean patient age was 30.4 (+23.7) years, and male-to-female ratio was 1.7:1 (38/22). Of the 61 C. diphtheriae isolates, 5 tested positive for the diphtheria toxin gene, and all results were negative by Elek test; 95% (61/64) of cases were cutaneous, including the C. ulcerans cases. The increase in reported human infections underscores the need to raise awareness among frontline healthcare practitioners to improve prevention.
摘要：
在法属圭亚那，人类感染白喉棒状杆菌物种复合物（CdSC）细菌的情况很少见，直到2016年，诊断病例数增加。我们进行了流行病学调查,多中心，2016年1月1日至2021年12月31日在法属圭亚那诊断出的所有人类CdSC感染的回顾性研究.在60例患者中总共观察到64次感染发作；白喉梭菌引起61次感染，溃疡梭菌引起3次感染。估计发病率从2016年的0.7例/10万人口增加到2021年的7.7例/10万人口。患者平均年龄为30.4（+23.7）岁，男女比例为1.7:1(38/22)。在61株白喉梭菌中，5白喉毒素基因检测呈阳性，所有结果经Elek检验均为阴性；95%(61/64)的病例为皮肤，包括C.溃疡病例。报告的人类感染的增加强调需要提高一线医疗保健从业人员的认识，以改善预防。
