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Abstract：
BACKGROUND: To establish a normative database for macular vessel density (VD) measured by optical coherence tomography angiography (OCTA) and explore the parameters related to the VD.
METHODS: An observational study in epidemiology. 5840 healthy elderly participants in Beichen district, Tianjin, China underwent detailed ophthalmic and systemic examinations. OCTA was performed in all subjects using a 6 × 6-mm line scan mode centered on the macula and the built-in software was used to quantify VD and stratify the retina.
RESULTS: One thousand four hundred sixty-one healthy elderly citizens (30.4% men) were included, with a median age of 60.0 years (8.0 years) and an age range of 50 to 87 years.VDs in the different plexuses: superficial capillary plexus (SCP) 43.9% (3.2%), deep capillary plexus (DCP) 44.3% (2.8%), outer capillary plexus (OCP) 21.9% (5.9%), choriocapillaris (CC) 52.1% (1.4%). 90% medical reference range of the VDs at different plexuses was reported. Age was correlated with the VDs of each capillary plexus. Sex was correlated with the VDs of DCP and OCP, and the VDs of DCP (p < 0.001) and OCP (p = 0.015) in women were higher than that in men. After age and sex adjustment, choroid average thickness was positively correlated with VDs of SCP (R = 0.067, p = 0.010) and DCP (R = 0.108, p < 0.001), ganglion cell layer (GCL) average thickness (R = 0.072, p = 0.006) was positively correlated with the VD of OCP, best-corrected visual acuity (BCVA) (R = 0.082, p = 0.002) was positively correlated with the VD of CC.
CONCLUSIONS: In this study, the normative VD database of the Chinese urban healthy elderly population measured by the OCTA was established, and parameters related to the VD of each capillary plexus were analyzed, providing new ideas for the future study of the relationship between macular VD and disease.
BACKGROUND: The Beichen Eye Study had been registered on the Chinese Clinical Trial Registry website (registry number: ChiCTR2000032280) on April 25, 2020.
METHODS: An observational study in epidemiology. 5840 healthy elderly participants in Beichen district, Tianjin, China underwent detailed ophthalmic and systemic examinations. OCTA was performed in all subjects using a 6 × 6-mm line scan mode centered on the macula and the built-in software was used to quantify VD and stratify the retina.
RESULTS: One thousand four hundred sixty-one healthy elderly citizens (30.4% men) were included, with a median age of 60.0 years (8.0 years) and an age range of 50 to 87 years.VDs in the different plexuses: superficial capillary plexus (SCP) 43.9% (3.2%), deep capillary plexus (DCP) 44.3% (2.8%), outer capillary plexus (OCP) 21.9% (5.9%), choriocapillaris (CC) 52.1% (1.4%). 90% medical reference range of the VDs at different plexuses was reported. Age was correlated with the VDs of each capillary plexus. Sex was correlated with the VDs of DCP and OCP, and the VDs of DCP (p < 0.001) and OCP (p = 0.015) in women were higher than that in men. After age and sex adjustment, choroid average thickness was positively correlated with VDs of SCP (R = 0.067, p = 0.010) and DCP (R = 0.108, p < 0.001), ganglion cell layer (GCL) average thickness (R = 0.072, p = 0.006) was positively correlated with the VD of OCP, best-corrected visual acuity (BCVA) (R = 0.082, p = 0.002) was positively correlated with the VD of CC.
CONCLUSIONS: In this study, the normative VD database of the Chinese urban healthy elderly population measured by the OCTA was established, and parameters related to the VD of each capillary plexus were analyzed, providing new ideas for the future study of the relationship between macular VD and disease.
BACKGROUND: The Beichen Eye Study had been registered on the Chinese Clinical Trial Registry website (registry number: ChiCTR2000032280) on April 25, 2020.
摘要：
背景：建立通过光学相干断层扫描血管造影（OCTA）测量的黄斑血管密度（VD）的规范数据库，并探索与VD相关的参数。
方法：流行病学观察性研究。北辰区5840名健康老年人参与者，天津,中国接受了详细的眼科和全身检查。使用以黄斑为中心的6×6-mm线扫描模式在所有受试者中进行OCTA，并使用内置软件量化VD并对视网膜进行分层。
结果：包括一千四百六十一名健康老年人（30.4％的男性），年龄中位数为60.0岁（8.0岁），年龄范围为50至87岁。不同丛的VDs:浅表毛细血管丛(SCP)43.9%(3.2%),深毛细血管丛(DCP)44.3%(2.8%)，外毛细血管丛（OCP）21.9%（5.9%），脉络膜毛细血管病（CC）52.1%（1.4%）。报告了不同丛的VD的90％医学参考范围。年龄与每个毛细血管丛的VD相关。性别与DCP和OCP的VD相关，女性的DCP（p<0.001）和OCP（p=0.015）的VD高于男性。经过年龄和性别调整后，脉络膜平均厚度与SCP(R=0.067,p=0.010)和DCP(R=0.108,p<0.001)的VDs呈正相关,神经节细胞层(GCL)平均厚度(R=0.072,p=0.006)与OCP的VD呈正相关,最佳矫正视力（BCVA）（R=0.082，p=0.002）与CC的VD呈正相关。
结论：在这项研究中，建立了由OCTA测量的中国城市健康老年人群的标准化VD数据库，并分析了与每个毛细血管丛VD相关的参数，为今后研究黄斑VD与疾病的关系提供新的思路。
背景：北辰眼科研究已于2020年4月25日在中国临床试验注册网站（注册号：ChiCTR2000032280）上注册。
方法：流行病学观察性研究。北辰区5840名健康老年人参与者，天津,中国接受了详细的眼科和全身检查。使用以黄斑为中心的6×6-mm线扫描模式在所有受试者中进行OCTA，并使用内置软件量化VD并对视网膜进行分层。
结果：包括一千四百六十一名健康老年人（30.4％的男性），年龄中位数为60.0岁（8.0岁），年龄范围为50至87岁。不同丛的VDs:浅表毛细血管丛(SCP)43.9%(3.2%),深毛细血管丛(DCP)44.3%(2.8%)，外毛细血管丛（OCP）21.9%（5.9%），脉络膜毛细血管病（CC）52.1%（1.4%）。报告了不同丛的VD的90％医学参考范围。年龄与每个毛细血管丛的VD相关。性别与DCP和OCP的VD相关，女性的DCP（p<0.001）和OCP（p=0.015）的VD高于男性。经过年龄和性别调整后，脉络膜平均厚度与SCP(R=0.067,p=0.010)和DCP(R=0.108,p<0.001)的VDs呈正相关,神经节细胞层(GCL)平均厚度(R=0.072,p=0.006)与OCP的VD呈正相关,最佳矫正视力（BCVA）（R=0.082，p=0.002）与CC的VD呈正相关。
结论：在这项研究中，建立了由OCTA测量的中国城市健康老年人群的标准化VD数据库，并分析了与每个毛细血管丛VD相关的参数，为今后研究黄斑VD与疾病的关系提供新的思路。
背景：北辰眼科研究已于2020年4月25日在中国临床试验注册网站（注册号：ChiCTR2000032280）上注册。
