PDF(Pubmed)
Abstract：
We describe humoral immune responses in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS-CoV-2 infection.
摘要：
我们描述了105例经实验室确认的SARS-CoV-2Omicron变体感染的非卧床患者的体液免疫反应。在发病5天内和疗养期间收集的干血斑（DBS）中，我们使用商业多重珠子测定法测量了针对祖先刺突蛋白受体结合域（RBD）和核衣壳（N）蛋白的结合抗体（bAb）。在急性疾病和恢复期之间，针对RBD的几何平均bAb浓度从1258至3189单位/mL增加了2.5倍，针对N蛋白的浓度从5.5至259单位/mL增加了47倍；较低的浓度与较大的几何平均比相关。配对DBS标本可用于评估对SARS-CoV-2感染的体液反应。
