%0 Journal Article
%T Antibody Response to Symptomatic Infection With SARS-CoV-2 Omicron Variant Viruses, December 2021-June 2022.
%A Sandford R
%A Yadav R
%A Noble EK
%A Sumner K
%A Joshi D
%A Tartof SY
%A Wernli KJ
%A Martin ET
%A Gaglani M
%A Zimmerman RK
%A Talbot HK
%A Grijalva CG
%A Belongia EA
%A Carlson C
%A Coughlin M
%A Flannery B
%A Pearce B
%A Rogier E
%J Influenza Other Respir Viruses
%V 18
%N 7
%D 2024 Jul
%M 39012045
%F 5.606
%R 10.1111/irv.13339
%X We describe humoral immune responses in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS-CoV-2 infection.