PDF(Pubmed)
Abstract：
UNASSIGNED: Sepsis is a significant contributor to both intensive care unit (ICU) admissions and mortality among patients in ICU, with a rising prevalence of obesity. There is a lack of extensive research on the correlation between TyGI and findings in patients with sepsis, especially in obese patients.
UNASSIGNED: This study used a retrospective cohort design and included patients with sepsis (≥18 years) from the Medical Information Mart for Intensive Care IV database. The association between TyGI and outcome was examined using multivariable logistic regression analysis.
UNASSIGNED: 8,840 patients with sepsis were included in the analysis. The in-ICU mortality rate was 9.7%. Non-survivors exhibited significantly greater TyGI levels than survivors [9.19(8.76-9.71) vs. 9.10(8.67-9.54), p < 0.001]. The adjusted multivariate regression model showed that elevated TyGI values were linked to a greater likelihood of death in ICU (odds ratio [OR] range 1.072-1.793, p < 0.001) and hospital (OR range 1.068-1.445, p = 0.005). Restricted Cubic Spline analysis revealed a nonlinear association between TyGI and in-ICU and in-hospital mortality risks within specified ranges. Subgroup analysis revealed interaction effects in the general obesity, abdominal obesity, and impaired fasting glucose subgroups (p = 0.014, 0.016, and < 0.001, respectively).
UNASSIGNED: TyGI was associated with an increased sepsis-related short-term mortality risk and adverse outcomes after ICU admission.
UNASSIGNED: This study used a retrospective cohort design and included patients with sepsis (≥18 years) from the Medical Information Mart for Intensive Care IV database. The association between TyGI and outcome was examined using multivariable logistic regression analysis.
UNASSIGNED: 8,840 patients with sepsis were included in the analysis. The in-ICU mortality rate was 9.7%. Non-survivors exhibited significantly greater TyGI levels than survivors [9.19(8.76-9.71) vs. 9.10(8.67-9.54), p < 0.001]. The adjusted multivariate regression model showed that elevated TyGI values were linked to a greater likelihood of death in ICU (odds ratio [OR] range 1.072-1.793, p < 0.001) and hospital (OR range 1.068-1.445, p = 0.005). Restricted Cubic Spline analysis revealed a nonlinear association between TyGI and in-ICU and in-hospital mortality risks within specified ranges. Subgroup analysis revealed interaction effects in the general obesity, abdominal obesity, and impaired fasting glucose subgroups (p = 0.014, 0.016, and < 0.001, respectively).
UNASSIGNED: TyGI was associated with an increased sepsis-related short-term mortality risk and adverse outcomes after ICU admission.
摘要：
■脓毒症是ICU患者中重症监护病房（ICU）入院和死亡率的重要原因，随着肥胖患病率的上升。关于TyGI与脓毒症患者发现之间的相关性缺乏广泛的研究，尤其是肥胖患者。
■本研究采用回顾性队列设计，纳入了重症监护医学信息集市IV数据库中的脓毒症患者（≥18岁）。使用多变量逻辑回归分析检查TyGI与结果之间的关联。
■8,840例脓毒症患者纳入分析。ICU病死率为9.7%。非幸存者的TyGI水平明显高于幸存者[9.19（8.76-9.71）vs.9.10(8.67-9.54),p<0.001]。调整后的多元回归模型显示，TyGI值升高与ICU（比值比[OR]范围1.072-1.793，p<0.001）和医院（OR范围1.068-1.445，p=0.005）中死亡的可能性更大。限制性三次样条分析显示，在指定范围内，TyGI与ICU和院内死亡风险之间存在非线性关联。亚组分析揭示了一般肥胖的交互作用，腹部肥胖，和空腹血糖受损亚组（分别为p=0.014、0.016和<0.001）。
■TyGI与ICU入住后脓毒症相关的短期死亡风险和不良结局增加相关。
■本研究采用回顾性队列设计，纳入了重症监护医学信息集市IV数据库中的脓毒症患者（≥18岁）。使用多变量逻辑回归分析检查TyGI与结果之间的关联。
■8,840例脓毒症患者纳入分析。ICU病死率为9.7%。非幸存者的TyGI水平明显高于幸存者[9.19（8.76-9.71）vs.9.10(8.67-9.54),p<0.001]。调整后的多元回归模型显示，TyGI值升高与ICU（比值比[OR]范围1.072-1.793，p<0.001）和医院（OR范围1.068-1.445，p=0.005）中死亡的可能性更大。限制性三次样条分析显示，在指定范围内，TyGI与ICU和院内死亡风险之间存在非线性关联。亚组分析揭示了一般肥胖的交互作用，腹部肥胖，和空腹血糖受损亚组（分别为p=0.014、0.016和<0.001）。
■TyGI与ICU入住后脓毒症相关的短期死亡风险和不良结局增加相关。
