{Reference Type}: Journal Article
{Title}: Association between the triglyceride glucose index and short-term mortality in septic patients with or without obesity: a retrospective cohort study.
{Author}: Lv Z;Wang J;Gu M;Zhou L;Shen S;Huang C;
{Journal}: Adipocyte
{Volume}: 13
{Issue}: 1
{Year}: 2024 Dec
{Factor}: 3.553
{DOI}: 10.1080/21623945.2024.2379867
{Abstract}: <B>UNASSIGNED: </B>Sepsis is a significant contributor to both intensive care unit (ICU) admissions and mortality among patients in ICU, with a rising prevalence of obesity. There is a lack of extensive research on the correlation between TyGI and findings in patients with sepsis, especially in obese patients.<BR><B>UNASSIGNED: </B>This study used a retrospective cohort design and included patients with sepsis (≥18 years) from the Medical Information Mart for Intensive Care IV database. The association between TyGI and outcome was examined using multivariable logistic regression analysis.<BR><B>UNASSIGNED: </B>8,840 patients with sepsis were included in the analysis. The in-ICU mortality rate was 9.7%. Non-survivors exhibited significantly greater TyGI levels than survivors [9.19(8.76-9.71) vs. 9.10(8.67-9.54), p < 0.001]. The adjusted multivariate regression model showed that elevated TyGI values were linked to a greater likelihood of death in ICU (odds ratio [OR] range 1.072-1.793, p < 0.001) and hospital (OR range 1.068-1.445, p = 0.005). Restricted Cubic Spline analysis revealed a nonlinear association between TyGI and in-ICU and in-hospital mortality risks within specified ranges. Subgroup analysis revealed interaction effects in the general obesity, abdominal obesity, and impaired fasting glucose subgroups (p = 0.014, 0.016, and < 0.001, respectively).<BR><B>UNASSIGNED: </B>TyGI was associated with an increased sepsis-related short-term mortality risk and adverse outcomes after ICU admission.